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Protein complex

ACTA2: actin, alpha 2, smooth muscle, aorta
ALS2: amyotrophic lateral sclerosis 2 (juvenile)
AR: androgen receptor
BRCA1: breast cancer 1, early onset
BRCA2: breast cancer 2, early onset
BSND: Bartter syndrome, infantile, with sensorineural deafness (Barttin)
CAPN3: calpain 3, (p94)
CFTR: cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CISD2: CDGSH iron sulfur domain 2
COL6A1: collagen, type VI, alpha 1
COL6A2: collagen, type VI, alpha 2
DMD: dystrophin
ERCC8: excision repair cross-complementing rodent repair deficiency, complementation group 8
FOXP3: forkhead box P3
GCH1: GTP cyclohydrolase 1
HTT: huntingtin
MEN1: multiple endocrine neoplasia I
MITF: microphthalmia-associated transcription factor
MYH9: myosin, heavy chain 9, non-muscle
OTX2: orthodenticle homeobox 2
PAX2: paired box 2
PRKAR1A: protein kinase, cAMP-dependent, regulatory, type I, alpha
PSEN2: presenilin 2 (Alzheimer disease 4)
RYR2: ryanodine receptor 2 (cardiac)
SOD1: superoxide dismutase 1, soluble
SOX9: SRY (sex determining region Y)-box 9
SRCAP: Snf2-related CREBBP activator protein
TP53: tumor protein p53
TSC1: tuberous sclerosis 1
Actin filament
AMP-activated protein kinase complex
- PRKAG2: protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Angiogenin-PRI complex
- ANG: angiogenin, ribonuclease, RNase A family, 5
AP-type membrane coat adaptor complex
- LDLRAP1: low density lipoprotein receptor adaptor protein 1
Aster
- PAFAH1B1: platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
BBSome
- BBS1: Bardet-Biedl syndrome 1
Beta-catenin destruction complex
- APC: adenomatous polyposis coli
- CTNNB1: catenin (cadherin-associated protein), beta 1, 88kDa
BRCA1-A complex
- BARD1: BRCA1 associated RING domain 1
- BRCA1: breast cancer 1, early onset
BRCA2-MAGE-D1 complex
- BRCA2: breast cancer 2, early onset
Catenin complex
- CDH1: cadherin 1, type 1, E-cadherin (epithelial)
- CTNNB1: catenin (cadherin-associated protein), beta 1, 88kDa
Catenin-TCF7L2 complex
- CTNNB1: catenin (cadherin-associated protein), beta 1, 88kDa
CNTFR-CLCF1 complex
- CLCF1: cardiotrophin-like cytokine factor 1
Cohesin complex
- SMC1A: structural maintenance of chromosomes 1A
- SMC3: structural maintenance of chromosomes 3
Cohesin core heterodimer
- SMC1A: structural maintenance of chromosomes 1A
CRLF-CLCF1 complex
- CLCF1: cardiotrophin-like cytokine factor 1
- CRLF1: cytokine receptor-like factor 1
Cyclin-dependent protein kinase activating kinase holoenzyme complex
- ERCC2: excision repair cross-complementing rodent repair deficiency, complementation group 2
Death-inducing signaling complex
- FAS: Fas (TNF receptor superfamily, member 6)
Dystrophin-associated glycoprotein complex
- CAV3: caveolin 3
- DMD: dystrophin
- SGCA: sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
- SGCB: sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
- SGCD: sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
- SGCE: sarcoglycan, epsilon
Elongator holoenzyme complex
- IKBKAP: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Endoplasmic reticulum Sec complex
- CFTR: cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Eukaryotic translation initiation factor 2B complex
- EIF2B1: eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
- EIF2B2: eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
- EIF2B3: eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
- EIF2B4: eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
- EIF2B5: eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
Exon-exon junction complex
- RBM8A: RNA binding motif protein 8A
Fanconi anaemia nuclear complex
- FANCA: Fanconi anemia, complementation group A
- FANCC: Fanconi anemia, complementation group C
- FANCG: Fanconi anemia, complementation group G
Ferritin complex
- FTL: ferritin, light polypeptide
Filamentous actin
- BRCA1: breast cancer 1, early onset
- ESPN: espin
- MYO1A: myosin IA
- MYO6: myosin VI
- PKD2: polycystic kidney disease 2 (autosomal dominant)
Fumarate reductase complex
- SDHA: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
- SDHB: succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
- SDHC: succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
- SDHD: succinate dehydrogenase complex, subunit D, integral membrane protein
Gamma-secretase complex
- PSEN1: presenilin 1
Gamma-tubulin complex
- BRCA1: breast cancer 1, early onset
- CEP290: centrosomal protein 290kDa
Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
- PIGA: phosphatidylinositol glycan anchor biosynthesis, class A
Haptoglobin-hemoglobin complex
- HBA2: hemoglobin, alpha 2
- HBB: hemoglobin, beta
Hemoglobin complex
- HBA2: hemoglobin, alpha 2
- HBB: hemoglobin, beta
Heterotrimeric G-protein complex
- GNAI3: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
- GNAS: GNAS complex locus
- GNAT2: guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Histone acetyltransferase complex
- ACTB: actin, beta
- KANSL1: KAT8 regulatory NSL complex subunit 1
- KAT6B: K(lysine) acetyltransferase 6B
Histone deacetylase complex
- SALL1: sal-like 1 (Drosophila)
IkappaB kinase complex
- IKBKG: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Intermediate filament
Intraflagellar transport particle
- IFT140: intraflagellar transport 140 homolog (Chlamydomonas)
Intraflagellar transport particle A
- IFT140: intraflagellar transport 140 homolog (Chlamydomonas)
Ion channel complex
Isoamylase complex
- AGL: amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
Kinetochore
MCM complex
- MCM6: minichromosome maintenance complex component 6
Mediator complex
- GLI3: GLI family zinc finger 3
- MED12: mediator complex subunit 12
Membrane coat
- LDLRAP1: low density lipoprotein receptor adaptor protein 1
Methyltransferase complex
- ACTB: actin, beta
- KANSL1: KAT8 regulatory NSL complex subunit 1
- KMT2D: myeloid/lymphoid or mixed-lineage leukemia 2
- MEN1: multiple endocrine neoplasia I
- TAF1: TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
Microtubule
Microtubule associated complex
Mismatch repair complex
- MLH1: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- MSH2: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
- MSH6: mutS homolog 6 (E. coli)
- PMS2: PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
- WRN: Werner syndrome, RecQ helicase-like
MMXD complex
- ERCC2: excision repair cross-complementing rodent repair deficiency, complementation group 2
Mre11 complex
- NBN: nibrin
- RAD50: RAD50 homolog (S. cerevisiae)
Myb complex
- FLNA: filamin A, alpha
Myosin complex
- MYBPC3: myosin binding protein C, cardiac
- MYH7: myosin, heavy chain 7, cardiac muscle, beta
- MYO6: myosin VI
NADH dehydrogenase complex
- MT-ND1: mitochondrially encoded NADH dehydrogenase 1
- MT-ND4: mitochondrially encoded NADH dehydrogenase 4
- MT-ND4L: mitochondrially encoded NADH dehydrogenase 4L
- MT-ND5: mitochondrially encoded NADH dehydrogenase 5
- MT-ND6: mitochondrially encoded NADH dehydrogenase 6
NADPH oxidase complex
- CYBA: cytochrome b-245, alpha polypeptide
- CYBB: cytochrome b-245, beta polypeptide
- NCF1: neutrophil cytosolic factor 1
- NCF2: neutrophil cytosolic factor 2
- NCF4: neutrophil cytosolic factor 4, 40kDa
NLRP1 inflammasome complex
- NLRP1: NLR family, pyrin domain containing 1
NLRP3 inflammasome complex
- NLRP3: NLR family, pyrin domain containing 3
Nuclear RNA export factor complex
- ATXN1: ataxin 1
Nucleotide-excision repair complex
- ERCC8: excision repair cross-complementing rodent repair deficiency, complementation group 8
- XPC: xeroderma pigmentosum, complementation group C
Ornithine carbamoyltransferase complex
- OTC: ornithine carbamoyltransferase
Palmitoyltransferase complex
- SPTLC1: serine palmitoyltransferase, long chain base subunit 1
PcG protein complex
- BCOR: BCL6 corepressor
Phosphorylase kinase complex
- PHKA2: phosphorylase kinase, alpha 2 (liver)
- PHKG2: phosphorylase kinase, gamma 2 (testis)
Polycystin complex
- PKD1: polycystic kidney disease 1 (autosomal dominant)
- PKD2: polycystic kidney disease 2 (autosomal dominant)
Pore complex
- AAAS: achalasia, adrenocortical insufficiency, alacrimia
Proteasome complex
- HSPB1: heat shock 27kDa protein 1
- VCP: valosin containing protein
Protein serine/threonine phosphatase complex
- PPP1R12A: protein phosphatase 1, regulatory subunit 12A
Proton-transporting two-sector ATPase complex
- MT-ATP6: mitochondrially encoded ATP synthase 6
Proton-transporting two-sector ATPase complex, proton-transporting domain
- MT-ATP6: mitochondrially encoded ATP synthase 6
Pyruvate dehydrogenase complex
- DLAT: dihydrolipoamide S-acetyltransferase
- PDHA1: pyruvate dehydrogenase (lipoamide) alpha 1
- PDHB: pyruvate dehydrogenase (lipoamide) beta
Receptor complex
Respiratory chain complex II
- SDHA: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
- SDHB: succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
- SDHC: succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
- SDHD: succinate dehydrogenase complex, subunit D, integral membrane protein
Ribonuclease H2 complex
- RNASEH2A: ribonuclease H2, subunit A
- RNASEH2B: ribonuclease H2, subunit B
- RNASEH2C: ribonuclease H2, subunit C
RNA cap binding complex
- FMR1: fragile X mental retardation 1
RNA polymerase complex
Signalosome
- MYH9: myosin, heavy chain 9, non-muscle
- NOD2: nucleotide-binding oligomerization domain containing 2
SMAD protein complex
- SMAD3: SMAD family member 3
- SMAD4: SMAD family member 4
SMC loading complex
- NIPBL: Nipped-B homolog (Drosophila)
Sodium:potassium-exchanging ATPase complex
- ATP1A2: ATPase, Na+/K+ transporting, alpha 2 polypeptide
- ATP1A3: ATPase, Na+/K+ transporting, alpha 3 polypeptide
Spindle
Spindle midzone
- CTDP1: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Spindle pole
- CTDP1: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
- DCTN1: dynactin 1
- SBDS: Shwachman-Bodian-Diamond syndrome
- SMC3: structural maintenance of chromosomes 3
- UMOD: uromodulin
Stereocilia ankle link complex
- USH2A: Usher syndrome 2A (autosomal recessive, mild)
Succinate dehydrogenase complex
- SDHA: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
- SDHB: succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
- SDHC: succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
- SDHD: succinate dehydrogenase complex, subunit D, integral membrane protein
SUN-KASH complex
- SYNE1: spectrin repeat containing, nuclear envelope 1
SWI/SNF superfamily-type complex
TCTN-B9D complex
- CEP290: centrosomal protein 290kDa
Transcriptional repressor complex
- GATA1: GATA binding protein 1 (globin transcription factor 1)
- SALL1: sal-like 1 (Drosophila)
- SKI: v-ski sarcoma viral oncogene homolog (avian)
- SMARCE1: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Transcription elongation factor complex
- CDC73: cell division cycle 73
- ERCC6: excision repair cross-complementing rodent repair deficiency, complementation group 6
- IKBKAP: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Transcription factor complex
Tricarboxylic acid cycle enzyme complex
- BCKDHA: branched chain keto acid dehydrogenase E1, alpha polypeptide
- BCKDHB: branched chain keto acid dehydrogenase E1, beta polypeptide
- DBT: dihydrolipoamide branched chain transacylase E2
Troponin complex
- TNNI3: troponin I type 3 (cardiac)
- TNNT2: troponin T type 2 (cardiac)
TSC1-TSC2 complex
- NEFL: neurofilament, light polypeptide
- TSC1: tuberous sclerosis 1
- TSC2: tuberous sclerosis 2
Tubulin complex
- MAPT: microtubule-associated protein tau
Ubiquitin ligase complex
- BARD1: BRCA1 associated RING domain 1
- BRCA1: breast cancer 1, early onset
- CUL7: cullin 7
- ERCC8: excision repair cross-complementing rodent repair deficiency, complementation group 8
- GAN: gigaxonin
WASH complex
- KIAA0196: KIAA0196

Source: Gene Ontology Consortium.


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