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- F5: coagulation factor V (proaccelerin, labile factor)
- F8: coagulation factor VIII, procoagulant component (hemophilia A)
- F9: coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)
- FAH: fumarylacetoacetate hydrolase (fumarylacetoacetase)
- FBN1: fibrillin 1
- FBN2: fibrillin 2 (congenital contractural arachnodactyly)
- FECH: ferrochelatase (protoporphyria)
- FGFR1: fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
- FGFR2: fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
- FGFR3: fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)
- FGFR4: fibroblast growth factor receptor 4
- FGFRL1: fibroblast growth factor receptor-like 1
- FH: fumarate hydratase
- FLCN: folliculin
- FLNA: filamin A, alpha (actin binding protein 280)
- FLT4: fms-related tyrosine kinase 4
- FMO3: flavin containing monooxygenase 3
- FMR1: fragile X mental retardation 1
- FOXC2: forkhead box C2 (MFH-1, mesenchyme forkhead 1)
- FOXP3: forkhead box P3
- FXN: frataxin
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