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Congenital leptin deficiency

Reviewed December 2013

What is congenital leptin deficiency?

Congenital leptin deficiency is a condition that causes severe obesity beginning in the first few months of life. Affected individuals are of normal weight at birth, but they are constantly hungry and quickly gain weight. Without treatment, the extreme hunger continues and leads to chronic excessive eating (hyperphagia) and obesity. Beginning in early childhood, affected individuals develop abnormal eating behaviors such as fighting with other children over food, hoarding food, and eating in secret.

People with congenital leptin deficiency also have hypogonadotropic hypogonadism, which is a condition caused by reduced production of hormones that direct sexual development. Without treatment, affected individuals experience delayed puberty or do not go through puberty, and may be unable to conceive children (infertile).

How common is congenital leptin deficiency?

Congenital leptin deficiency is a rare disorder. Only a few dozen cases have been reported in the medical literature.

What genes are related to congenital leptin deficiency?

Congenital leptin deficiency is caused by mutations in the LEP gene. This gene provides instructions for making a hormone called leptin, which is involved in the regulation of body weight. Normally, the body's fat cells release leptin in proportion to their size. As fat accumulates in cells, more leptin is produced. This rise in leptin indicates that fat stores are increasing.

Leptin attaches (binds) to and activates a protein called the leptin receptor, fitting into the receptor like a key into a lock. The leptin receptor protein is found on the surface of cells in many organs and tissues of the body including a part of the brain called the hypothalamus. The hypothalamus controls hunger and thirst as well as other functions such as sleep, moods, and body temperature. It also regulates the release of many hormones that have functions throughout the body. In the hypothalamus, the binding of leptin to its receptor triggers a series of chemical signals that affect hunger and help produce a feeling of fullness (satiety).

LEP gene mutations that cause congenital leptin deficiency lead to an absence of leptin. As a result, the signaling that triggers feelings of satiety does not occur, leading to the excessive hunger and weight gain associated with this disorder. Because hypogonadotropic hypogonadism occurs in congenital leptin deficiency, researchers suggest that leptin signaling is also involved in regulating the hormones that control sexual development. However, the specifics of this involvement and how it may be altered in congenital leptin deficiency are unknown.

Congenital leptin deficiency is a rare cause of obesity. Researchers are studying the factors involved in more common forms of obesity.

Related Gene(s)

Changes in this gene are associated with congenital leptin deficiency.

  • LEP

How do people inherit congenital leptin deficiency?

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

Where can I find information about diagnosis or management of congenital leptin deficiency?

These resources address the diagnosis or management of congenital leptin deficiency and may include treatment providers.

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: How Are Obesity and Overweight Diagnosed? (http://www.nichd.nih.gov/health/topics/obesity/conditioninfo/pages/diagnosed.aspx)
  • Genetics of Obesity Study (http://www.goos.org.uk/home)
  • Genetic Testing Registry: Obesity, severe, due to leptin deficiency (http://www.ncbi.nlm.nih.gov/gtr/conditions/CN069970)
  • National Heart, Lung, and Blood Institute: How Are Overweight and Obesity Treated? (http://www.nhlbi.nih.gov/health/health-topics/topics/obe/treatment.html)

You might also find information on the diagnosis or management of congenital leptin deficiency in Educational resources (http://www.ghr.nlm.nih.gov/condition/congenital-leptin-deficiency/show/Educational+resources) and Patient support (http://www.ghr.nlm.nih.gov/condition/congenital-leptin-deficiency/show/Patient+support).

General information about the diagnosis (http://ghr.nlm.nih.gov/handbook/consult/diagnosis) and management (http://ghr.nlm.nih.gov/handbook/consult/treatment) of genetic conditions is available in the Handbook. Read more about genetic testing (http://ghr.nlm.nih.gov/handbook/testing), particularly the difference between clinical tests and research tests (http://ghr.nlm.nih.gov/handbook/testing/researchtesting).

To locate a healthcare provider, see How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

Where can I find additional information about congenital leptin deficiency?

You may find the following resources about congenital leptin deficiency helpful. These materials are written for the general public.

You may also be interested in these resources, which are designed for healthcare professionals and researchers.

What other names do people use for congenital leptin deficiency?

  • LEPD
  • leptin deficiency
  • obesity due to congenital leptin deficiency
  • obesity, morbid, due to leptin deficiency
  • obesity, morbid, nonsyndromic 1
  • obesity, severe, due to leptin deficiency

For more information about naming genetic conditions, see the Genetics Home Reference Condition Naming Guidelines (http://ghr.nlm.nih.gov/ConditionNameGuide) and How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.

What if I still have specific questions about congenital leptin deficiency?

Ask the Genetic and Rare Diseases Information Center (http://rarediseases.info.nih.gov/GARD/).

What glossary definitions help with understanding congenital leptin deficiency?

autosomal ; autosomal recessive ; cell ; chronic ; congenital ; deficiency ; excessive eating ; fat cells ; gene ; hormone ; hyperphagia ; hypogonadism ; hypogonadotropic ; hypothalamus ; infertile ; inherited ; protein ; puberty ; receptor ; recessive ; satiety

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).

References

  • Blüher S, Shah S, Mantzoros CS. Leptin deficiency: clinical implications and opportunities for therapeutic interventions. J Investig Med. 2009 Oct;57(7):784-8. doi: 10.231/JIM.0b013e3181b9163d. Review. (http://www.ncbi.nlm.nih.gov/pubmed/19730134?dopt=Abstract)
  • Dubern B, Clement K. Leptin and leptin receptor-related monogenic obesity. Biochimie. 2012 Oct;94(10):2111-5. doi: 10.1016/j.biochi.2012.05.010. Epub 2012 May 22. Review. (http://www.ncbi.nlm.nih.gov/pubmed/22627381?dopt=Abstract)
  • Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA, O'Rahilly S. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med. 1999 Sep 16;341(12):879-84. (http://www.ncbi.nlm.nih.gov/pubmed/10486419?dopt=Abstract)
  • Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002 Oct;110(8):1093-103. (http://www.ncbi.nlm.nih.gov/pubmed/12393845?dopt=Abstract)
  • Fatima W, Shahid A, Imran M, Manzoor J, Hasnain S, Rana S, Mahmood S. Leptin deficiency and leptin gene mutations in obese children from Pakistan. Int J Pediatr Obes. 2011 Oct;6(5-6):419-27. doi: 10.3109/17477166.2011.608431. Epub 2011 Aug 19. (http://www.ncbi.nlm.nih.gov/pubmed/21854111?dopt=Abstract)
  • Gibson WT, Farooqi IS, Moreau M, DePaoli AM, Lawrence E, O'Rahilly S, Trussell RA. Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. J Clin Endocrinol Metab. 2004 Oct;89(10):4821-6. (http://www.ncbi.nlm.nih.gov/pubmed/15472169?dopt=Abstract)
  • Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997 Jun 26;387(6636):903-8. (http://www.ncbi.nlm.nih.gov/pubmed/9202122?dopt=Abstract)
  • O'Rahilly S. Leptin: defining its role in humans by the clinical study of genetic disorders. Nutr Rev. 2002 Oct;60(10 Pt 2):S30-4; discussion S68-84, 85-7. Review. (http://www.ncbi.nlm.nih.gov/pubmed/12403081?dopt=Abstract)
  • Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab. 1999 Oct;84(10):3686-95. Erratum in: J Clin Endocrinol Metab 2000 Jan;85(1):416. (http://www.ncbi.nlm.nih.gov/pubmed/10523015?dopt=Abstract)
  • Paz-Filho G, Wong ML, Licinio J. Ten years of leptin replacement therapy. Obes Rev. 2011 May;12(5):e315-23. doi: 10.1111/j.1467-789X.2010.00840.x. Epub 2011 Mar 17. Review. (http://www.ncbi.nlm.nih.gov/pubmed/21410864?dopt=Abstract)
  • Saeed S, Butt TA, Anwer M, Arslan M, Froguel P. High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families. Mol Genet Metab. 2012 May;106(1):121-6. doi: 10.1016/j.ymgme.2012.03.001. Epub 2012 Mar 10. Erratum in: Mol Genet Metab. 2013 Aug;109(4):404. (http://www.ncbi.nlm.nih.gov/pubmed/22463805?dopt=Abstract)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: December 2013
Published: July 28, 2014