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Genetics Home Reference: your guide to understanding genetic conditions
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Myoclonic epilepsy with ragged-red fibers

(often shortened to MERRF)
Reviewed May 2014

What is MERRF?

Myoclonic epilepsy with ragged-red fibers (MERRF) is a disorder that affects many parts of the body, particularly the muscles and nervous system. In most cases, the signs and symptoms of this disorder appear during childhood or adolescence. The features of MERRF vary widely among affected individuals, even among members of the same family.

MERRF is characterized by muscle twitches (myoclonus), weakness (myopathy), and progressive stiffness (spasticity). When the muscle cells of affected individuals are stained and viewed under a microscope, these cells usually appear abnormal. These abnormal muscle cells are called ragged-red fibers. Other features of MERRF include recurrent seizures (epilepsy), difficulty coordinating movements (ataxia), a loss of sensation in the extremities (peripheral neuropathy), and slow deterioration of intellectual function (dementia). People with this condition may also develop hearing loss or optic atrophy, which is the degeneration (atrophy) of nerve cells that carry visual information from the eyes to the brain. Affected individuals sometimes have short stature and a form of heart disease known as cardiomyopathy. Less commonly, people with MERRF develop fatty tumors, called lipomas, just under the surface of the skin.

How common is MERRF?

MERRF is a rare condition; its prevalence is unknown. MERRF is part of a group of conditions known as mitochondrial disorders, which affect an estimated 1 in 5,000 people worldwide.

What are the genetic changes related to MERRF?

Mutations in the MT-TK gene are the most common cause of MERRF, occurring in more than 80 percent of all cases. Less frequently, mutations in the MT-TL1, MT-TH, and MT-TS1 genes have been reported to cause the signs and symptoms of MERRF. People with mutations in the MT-TL1, MT-TH, or MT-TS1 gene typically have signs and symptoms of other mitochondrial disorders as well as those of MERRF.

The MT-TK, MT-TL1, MT-TH, and MT-TS1 genes are contained in mitochondrial DNA (mtDNA). Mitochondria are structures within cells that use oxygen to convert the energy from food into a form cells can use through a process called oxidative phosphorylation. Although most DNA is packaged in chromosomes within the nucleus, mitochondria also have a small amount of their own DNA. The genes associated with MERRF provide instructions for making molecules called transfer RNAs, which are chemical cousins of DNA. These molecules help assemble protein building blocks called amino acids into full-length, functioning proteins within mitochondria. These proteins perform the steps of oxidative phosphorylation.

Mutations that cause MERRF impair the ability of mitochondria to make proteins, use oxygen, and produce energy. These mutations particularly affect organs and tissues with high energy requirements, such as the brain and muscles. Researchers have not determined how changes in mtDNA lead to the specific signs and symptoms of MERRF.

A small percentage of MERRF cases are caused by mutations in other mitochondrial genes, and in some cases the cause of the condition is unknown.

Related Gene(s)

Changes in these genes are associated with myoclonic epilepsy with ragged-red fibers.

  • MT-TF
  • MT-TH
  • MT-TK
  • MT-TL1
  • MT-TP
  • MT-TS1
  • MT-TS2
  • MT-TT

How do people inherit MERRF?

MERRF is inherited in a mitochondrial pattern, which is also known as maternal inheritance. This pattern of inheritance applies to genes contained in mtDNA. Because egg cells, but not sperm cells, contribute mitochondria to the developing embryo, only females pass mitochondrial conditions to their children. Mitochondrial disorders can appear in every generation of a family and can affect both males and females, but fathers do not pass mitochondrial traits to their children.

In most cases, people with MERRF inherit an altered mitochondrial gene from their mother, who may or may not show symptoms of the disorder. Less commonly, the disorder results from a new mutation in a mitochondrial gene and occurs in people with no family history of MERRF.

Where can I find information about diagnosis or management of MERRF?

These resources address the diagnosis or management of MERRF and may include treatment providers.

  • Gene Review: MERRF (http://www.ncbi.nlm.nih.gov/books/NBK1520)
  • Genetic Testing Registry: Myoclonus with epilepsy with ragged red fibers (http://www.ncbi.nlm.nih.gov/gtr/conditions/C0162672)
  • Kennedy Krieger Institute: Mitochondrial Disorders (http://www.kennedykrieger.org/patient-care/diagnoses-disorders/mitochondrial-disorders)
  • MedlinePlus Encyclopedia: Lipoma (http://www.nlm.nih.gov/medlineplus/ency/imagepages/1209.htm)
  • MedlinePlus Encyclopedia: Optic nerve atrophy (http://www.nlm.nih.gov/medlineplus/ency/article/001622.htm)
  • MedlinePlus Encyclopedia: Peripheral Neuropathy (http://www.nlm.nih.gov/medlineplus/ency/article/000593.htm)
  • MitoAction: Tips and Tools for Living with Mito (http://www.mitoaction.org/tips-and-tools-for-living-with-mito)
  • United Mitochondrial Disease Foundation: Treatments and Therapies (http://www.umdf.org/site/pp.aspx?c=8qKOJ0MvF7LUG&b=7934635)

You might also find information on the diagnosis or management of MERRF in Educational resources (http://www.ghr.nlm.nih.gov/condition/myoclonic-epilepsy-with-ragged-red-fibers/show/Educational+resources) and Patient support (http://www.ghr.nlm.nih.gov/condition/myoclonic-epilepsy-with-ragged-red-fibers/show/Patient+support).

General information about the diagnosis (http://ghr.nlm.nih.gov/handbook/consult/diagnosis) and management (http://ghr.nlm.nih.gov/handbook/consult/treatment) of genetic conditions is available in the Handbook. Read more about genetic testing (http://ghr.nlm.nih.gov/handbook/testing), particularly the difference between clinical tests and research tests (http://ghr.nlm.nih.gov/handbook/testing/researchtesting).

To locate a healthcare provider, see How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

Where can I find additional information about MERRF?

You may find the following resources about MERRF helpful. These materials are written for the general public.

You may also be interested in these resources, which are designed for healthcare professionals and researchers.

What other names do people use for MERRF?

  • Fukuhara Disease
  • MERRF syndrome
  • myoclonic epilepsy associated with ragged-red fibers
  • myoencephalopathy ragged-red fiber disease

For more information about naming genetic conditions, see the Genetics Home Reference Condition Naming Guidelines (http://ghr.nlm.nih.gov/ConditionNameGuide) and How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.

What if I still have specific questions about MERRF?

Ask the Genetic and Rare Diseases Information Center (http://rarediseases.info.nih.gov/GARD/).

What glossary definitions help with understanding MERRF?

acids ; ataxia ; atrophy ; cardiomyopathy ; dementia ; DNA ; egg ; electron ; embryo ; epilepsy ; family history ; gene ; inherit ; inheritance ; inherited ; maternal ; maternal inheritance ; mitochondria ; muscle cells ; mutation ; myoclonus ; nervous system ; neuropathy ; new mutation ; nucleus ; optic atrophy ; oxidative phosphorylation ; oxygen ; pattern of inheritance ; peripheral ; peripheral neuropathy ; phosphorylation ; prevalence ; protein ; short stature ; spasticity ; sperm ; stature ; syndrome

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).

References

  • Blakely EL, Trip SA, Swalwell H, He L, Wren DR, Rich P, Turnbull DM, Omer SE, Taylor RW. A new mitochondrial transfer RNAPro gene mutation associated with myoclonic epilepsy with ragged-red fibers and other neurological features. Arch Neurol. 2009 Mar;66(3):399-402. doi: 10.1001/archneurol.2008.576. (http://www.ncbi.nlm.nih.gov/pubmed/19273760?dopt=Abstract)
  • Cardaioli E, Malfatti E, Da Pozzo P, Gallus GN, Carluccio MA, Rufa A, Volpi N, Dotti MT, Federico A. Progressive mitochondrial myopathy, deafness, and sporadic seizures associated with a novel mutation in the mitochondrial tRNASer(AGY) gene. J Neurol Sci. 2011 Apr 15;303(1-2):142-5. doi: 10.1016/j.jns.2010.12.020. Epub 2011 Jan 22. (http://www.ncbi.nlm.nih.gov/pubmed/21257182?dopt=Abstract)
  • del Mar O'Callaghan M, Emperador S, López-Gallardo E, Jou C, Buján N, Montero R, Garcia-Cazorla A, Gonzaga D, Ferrer I, Briones P, Ruiz-Pesini E, Pineda M, Artuch R, Montoya J. New mitochondrial DNA mutations in tRNA associated with three severe encephalopamyopathic phenotypes: neonatal, infantile, and childhood onset. Neurogenetics. 2012 Aug;13(3):245-50. doi: 10.1007/s10048-012-0322-0. Epub 2012 May 26. (http://www.ncbi.nlm.nih.gov/pubmed/22638997?dopt=Abstract)
  • Deschauer M, Müller T, Wieser T, Schulte-Mattler W, Kornhuber M, Zierz S. Hearing impairment is common in various phenotypes of the mitochondrial DNA A3243G mutation. Arch Neurol. 2001 Nov;58(11):1885-8. (http://www.ncbi.nlm.nih.gov/pubmed/11708999?dopt=Abstract)
  • DiMauro S. Mitochondrial diseases. Biochim Biophys Acta. 2004 Jul 23;1658(1-2):80-8. Review. (http://www.ncbi.nlm.nih.gov/pubmed/15282178?dopt=Abstract)
  • Gene Review: MERRF (http://www.ncbi.nlm.nih.gov/books/NBK1520)
  • Mancuso M, Filosto M, Mootha VK, Rocchi A, Pistolesi S, Murri L, DiMauro S, Siciliano G. A novel mitochondrial tRNAPhe mutation causes MERRF syndrome. Neurology. 2004 Jun 8;62(11):2119-21. (http://www.ncbi.nlm.nih.gov/pubmed/15184630?dopt=Abstract)
  • Mancuso M, Petrozzi L, Filosto M, Nesti C, Rocchi A, Choub A, Pistolesi S, Massetani R, Fontanini G, Siciliano G. MERRF syndrome without ragged-red fibers: the need for molecular diagnosis. Biochem Biophys Res Commun. 2007 Mar 23;354(4):1058-60. Epub 2007 Jan 26. (http://www.ncbi.nlm.nih.gov/pubmed/17275787?dopt=Abstract)
  • Melone MA, Tessa A, Petrini S, Lus G, Sampaolo S, di Fede G, Santorelli FM, Cotrufo R. Revelation of a new mitochondrial DNA mutation (G12147A) in a MELAS/MERFF phenotype. Arch Neurol. 2004 Feb;61(2):269-72. (http://www.ncbi.nlm.nih.gov/pubmed/14967777?dopt=Abstract)
  • Moraes CT, Ciacci F, Bonilla E, Jansen C, Hirano M, Rao N, Lovelace RE, Rowland LP, Schon EA, DiMauro S. Two novel pathogenic mitochondrial DNA mutations affecting organelle number and protein synthesis. Is the tRNA(Leu(UUR)) gene an etiologic hot spot? J Clin Invest. 1993 Dec;92(6):2906-15. (http://www.ncbi.nlm.nih.gov/pubmed/8254046?dopt=Abstract)
  • OMIM: MYOCLONIC EPILEPSY ASSOCIATED WITH RAGGED-RED FIBERS (http://omim.org/entry/545000)
  • Nakamura M, Nakano S, Goto Y, Ozawa M, Nagahama Y, Fukuyama H, Akiguchi I, Kaji R, Kimura J. A novel point mutation in the mitochondrial tRNA(Ser(UCN)) gene detected in a family with MERRF/MELAS overlap syndrome. Biochem Biophys Res Commun. 1995 Sep 5;214(1):86-93. (http://www.ncbi.nlm.nih.gov/pubmed/7669057?dopt=Abstract)
  • Pulkes T, Liolitsa D, Eunson LH, Rose M, Nelson IP, Rahman S, Poulton J, Marchington DR, Landon DN, Debono AG, Morgan-Hughes JA, Hanna MG. New phenotypic diversity associated with the mitochondrial tRNA(SerUCN) gene mutation. Neuromuscul Disord. 2005 May;15(5):364-71. (http://www.ncbi.nlm.nih.gov/pubmed/15833431?dopt=Abstract)
  • Taylor RW, Schaefer AM, McDonnell MT, Petty RK, Thomas AM, Blakely EL, Hayes CM, McFarland R, Turnbull DM. Catastrophic presentation of mitochondrial disease due to a mutation in the tRNA(His) gene. Neurology. 2004 Apr 27;62(8):1420-3. (http://www.ncbi.nlm.nih.gov/pubmed/15111688?dopt=Abstract)
  • Teive HA, Munhoz RP, Muzzio JA, Scola RH, Kay CK, Raskin S, Werneck LC, Bruhn H. Cerebellar ataxia, myoclonus, cervical lipomas, and MERRF syndrome. Case report. Mov Disord. 2008 Jun 15;23(8):1191-2. doi: 10.1002/mds.21990. (http://www.ncbi.nlm.nih.gov/pubmed/18412280?dopt=Abstract)
  • Tuppen HA, Naess K, Kennaway NG, Al-Dosary M, Lesko N, Yarham JW, Bruhn H, Wibom R, Nennesmo I, Weleber RG, Blakely EL, Taylor RW, McFarland R. Mutations in the mitochondrial tRNA Ser(AGY) gene are associated with deafness, retinal degeneration, myopathy and epilepsy. Eur J Hum Genet. 2012 Aug;20(8):897-904. doi: 10.1038/ejhg.2012.44. Epub 2012 Feb 29. Erratum in: Eur J Hum Genet. 2012 Aug;20(8):910. (http://www.ncbi.nlm.nih.gov/pubmed/22378285?dopt=Abstract)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: May 2014
Published: October 9, 2014