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Simpson-Golabi-Behmel syndrome

Reviewed February 2008

What is Simpson-Golabi-Behmel syndrome?

Simpson-Golabi-Behmel syndrome is a condition that affects many parts of the body and occurs primarily in males. This condition is classified as an overgrowth syndrome, which means that affected infants are considerably larger than normal at birth (macrosomia) and continue to grow and gain weight at an unusual rate. The other signs and symptoms of Simpson-Golabi-Behmel syndrome vary widely. The most severe cases are life-threatening before birth or in infancy, whereas people with milder cases often live into adulthood.

People with Simpson-Golabi-Behmel syndrome have distinctive facial features including widely spaced eyes (ocular hypertelorism), an unusually large mouth (macrostomia), a large tongue (macroglossia) that may have a deep groove or furrow down the middle, a broad nose with an upturned tip, and abnormalities affecting the roof of the mouth (the palate). The facial features are often described as "coarse" in older children and adults with this condition.

Other features of Simpson-Golabi-Behmel syndrome involve the chest and abdomen. Affected infants may be born with one or more extra nipples, an abnormal opening in the muscle covering the abdomen (diastasis recti), a soft out-pouching around the belly-button (an umbilical hernia), or a hole in the diaphragm (a diaphragmatic hernia) that allows the stomach and intestines to move into the chest and crowd the developing heart and lungs.

Simpson-Golabi-Behmel syndrome can also cause heart defects, malformed or abnormally large kidneys, an enlarged liver and spleen (hepatosplenomegaly), and skeletal abnormalities. Additionally, the syndrome can affect the development of the gastrointestinal system, urinary system, and genitalia. Some people with this condition have mild to severe intellectual disability, while others have normal intelligence.

About 10 percent of people with Simpson-Golabi-Behmel syndrome develop cancerous or noncancerous tumors in early childhood. The most common tumors are a rare form of kidney cancer called Wilms tumor and a cancerous tumor called a neuroblastoma that arises in developing nerve cells.

How common is Simpson-Golabi-Behmel syndrome?

The incidence of Simpson-Golabi-Behmel syndrome is unknown. At least 130 people worldwide have been diagnosed with this disorder.

What genes are related to Simpson-Golabi-Behmel syndrome?

Mutations in the GPC3 gene are responsible for some cases of Simpson-Golabi-Behmel syndrome. This gene provides instructions for making a protein called glypican 3, which is involved in the regulation of cell growth and division (cell proliferation). Researchers believe that the GPC3 protein can also cause certain cells to self-destruct (undergo apoptosis) when they are no longer needed, which can help establish the body's shape.

GPC3 mutations can delete part or all of the gene, or alter the structure of glypican 3. These mutations prevent the protein from performing its usual functions, which may contribute to an increased rate of cell growth and cell division starting before birth. It is unclear, however, how a shortage of functional glypican 3 causes overgrowth of the entire body and the other abnormalities characteristic of Simpson-Golabi-Behmel syndrome.

Some individuals with Simpson-Golabi-Behmel syndrome do not have identified mutations in the GPC3 gene. In these cases, the cause of the condition is unknown.

Related Gene(s)

Changes in this gene are associated with Simpson-Golabi-Behmel syndrome.

  • GPC3

How do people inherit Simpson-Golabi-Behmel syndrome?

This condition is inherited in an X-linked pattern. A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes in each cell. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. Because females have two copies of the X chromosome, one altered copy of the gene in each cell usually leads to less severe symptoms in females than in males, or may cause no symptoms at all.

Some females who have one altered copy of the GPC3 gene have distinctive facial features including an upturned nose, a wide mouth, and a prominent chin. Their fingernails may be malformed and they can have extra nipples. Skeletal abnormalities, including extra spinal bones (vertebrae), are also possible in affected females. Other females who carry one altered copy of the GPC3 gene do not have these features or any other medical problems associated with Simpson-Golabi-Behmel syndrome.

Where can I find information about diagnosis or management of Simpson-Golabi-Behmel syndrome?

These resources address the diagnosis or management of Simpson-Golabi-Behmel syndrome and may include treatment providers.

  • Gene Review: Simpson-Golabi-Behmel Syndrome Type 1 (http://www.ncbi.nlm.nih.gov/books/NBK1219)
  • Genetic Testing Registry: Simpson-Golabi-Behmel syndrome (http://www.ncbi.nlm.nih.gov/gtr/conditions/C0796154)
  • MedlinePlus Encyclopedia: Diastasis Recti (http://www.nlm.nih.gov/medlineplus/ency/article/001602.htm)
  • MedlinePlus Encyclopedia: Macrosomia (http://www.nlm.nih.gov/medlineplus/ency/article/002251.htm)

You might also find information on the diagnosis or management of Simpson-Golabi-Behmel syndrome in Educational resources (http://www.ghr.nlm.nih.gov/condition/simpson-golabi-behmel-syndrome/show/Educational+resources) and Patient support (http://www.ghr.nlm.nih.gov/condition/simpson-golabi-behmel-syndrome/show/Patient+support).

General information about the diagnosis (http://ghr.nlm.nih.gov/handbook/consult/diagnosis) and management (http://ghr.nlm.nih.gov/handbook/consult/treatment) of genetic conditions is available in the Handbook. Read more about genetic testing (http://ghr.nlm.nih.gov/handbook/testing), particularly the difference between clinical tests and research tests (http://ghr.nlm.nih.gov/handbook/testing/researchtesting).

To locate a healthcare provider, see How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

Where can I find additional information about Simpson-Golabi-Behmel syndrome?

You may find the following resources about Simpson-Golabi-Behmel syndrome helpful. These materials are written for the general public.

You may also be interested in these resources, which are designed for healthcare professionals and researchers.

What other names do people use for Simpson-Golabi-Behmel syndrome?

  • DGSX
  • mental retardation-overgrowth syndrome
  • SDYS
  • SGBS
  • SGBS1
  • Simpson dysplasia syndrome
  • Simpson syndrome

For more information about naming genetic conditions, see the Genetics Home Reference Condition Naming Guidelines (http://ghr.nlm.nih.gov/ConditionNameGuide) and How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.

What if I still have specific questions about Simpson-Golabi-Behmel syndrome?

Ask the Genetic and Rare Diseases Information Center (http://rarediseases.info.nih.gov/GARD/).

What glossary definitions help with understanding Simpson-Golabi-Behmel syndrome?

apoptosis ; cancer ; cell ; cell division ; cell proliferation ; chromosome ; disability ; dysplasia ; gastrointestinal ; gene ; genitalia ; hepatosplenomegaly ; hernia ; hypertelorism ; incidence ; inherited ; kidney ; macrocephaly ; macroglossia ; macrostomia ; mental retardation ; ocular hypertelorism ; palate ; proliferation ; protein ; sex chromosomes ; stomach ; syndrome ; tumor ; Wilms tumor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).

References

  • DeBaun MR, Ess J, Saunders S. Simpson Golabi Behmel syndrome: progress toward understanding the molecular basis for overgrowth, malformation, and cancer predisposition. Mol Genet Metab. 2001 Apr;72(4):279-86. Review. (http://www.ncbi.nlm.nih.gov/pubmed/11286501?dopt=Abstract)
  • Gene Review: Simpson-Golabi-Behmel Syndrome Type 1 (http://www.ncbi.nlm.nih.gov/books/NBK1219)
  • Lapunzina P. Risk of tumorigenesis in overgrowth syndromes: a comprehensive review. Am J Med Genet C Semin Med Genet. 2005 Aug 15;137C(1):53-71. Review. (http://www.ncbi.nlm.nih.gov/pubmed/16010678?dopt=Abstract)
  • Li M, Shuman C, Fei YL, Cutiongco E, Bender HA, Stevens C, Wilkins-Haug L, Day-Salvatore D, Yong SL, Geraghty MT, Squire J, Weksberg R. GPC3 mutation analysis in a spectrum of patients with overgrowth expands the phenotype of Simpson-Golabi-Behmel syndrome. Am J Med Genet. 2001 Aug 1;102(2):161-8. (http://www.ncbi.nlm.nih.gov/pubmed/11477610?dopt=Abstract)
  • Rodríguez-Criado G, Magano L, Segovia M, Gurrieri F, Neri G, González-Meneses A, Gómez de Terreros I, Valdéz R, Gracia R, Lapunzina P. Clinical and molecular studies on two further families with Simpson-Golabi-Behmel syndrome. Am J Med Genet A. 2005 Oct 15;138A(3):272-7. (http://www.ncbi.nlm.nih.gov/pubmed/16158429?dopt=Abstract)
  • Sakazume S, Okamoto N, Yamamoto T, Kurosawa K, Numabe H, Ohashi Y, Kako Y, Nagai T, Ohashi H. GPC3 mutations in seven patients with Simpson-Golabi-Behmel syndrome. Am J Med Genet A. 2007 Aug 1;143A(15):1703-7. (http://www.ncbi.nlm.nih.gov/pubmed/17603795?dopt=Abstract)
  • Young EL, Wishnow R, Nigro MA. Expanding the clinical picture of Simpson-Golabi-Behmel syndrome. Pediatr Neurol. 2006 Feb;34(2):139-42. (http://www.ncbi.nlm.nih.gov/pubmed/16458828?dopt=Abstract)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: February 2008
Published: October 20, 2014