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X-linked congenital stationary night blindness

Reviewed May 2009

What is X-linked congenital stationary night blindness?

X-linked congenital stationary night blindness is a disorder of the retina, which is the specialized tissue at the back of the eye that detects light and color. People with this condition typically have difficulty seeing in low light (night blindness). They also have other vision problems, including loss of sharpness (reduced acuity), severe nearsightedness (high myopia), involuntary movements of the eyes (nystagmus), and eyes that do not look in the same direction (strabismus). Color vision is typically not affected by this disorder.

The vision problems associated with this condition are congenital, which means they are present from birth. They tend to remain stable (stationary) over time.

Researchers have identified two major types of X-linked congenital stationary night blindness: the complete form and the incomplete form. The types have very similar signs and symptoms. However, everyone with the complete form has night blindness, while not all people with the incomplete form have night blindness. The types are distinguished by their genetic cause and by the results of a test called an electroretinogram, which measures the function of the retina.

How common is X-linked congenital stationary night blindness?

The prevalence of this condition is unknown. It appears to be more common in people of Dutch-German Mennonite descent. However, this disorder has been reported in families with many different ethnic backgrounds. The incomplete form is more common than the complete form.

What genes are related to X-linked congenital stationary night blindness?

Mutations in the NYX and CACNA1F genes cause the complete and incomplete forms of X-linked congenital stationary night blindness, respectively. The proteins produced from these genes play critical roles in the retina.

Within the retina, the NYX and CACNA1F proteins are located on the surface of light-detecting cells called photoreceptors. The retina contains two types of photoreceptor cells: rods and cones. Rods are needed for vision in low light. Cones are needed for vision in bright light, including color vision. The NYX and CACNA1F proteins ensure that visual signals are passed from rods and cones to other retinal cells called bipolar cells, which is an essential step in the transmission of visual information from the eyes to the brain.

Mutations in the NYX or CACNA1F gene disrupt the transmission of visual signals between photoreceptors and retinal bipolar cells, which impairs vision. In people with the complete form of X-linked congenital stationary night blindness (resulting from NYX mutations), the function of rods is severely disrupted, while the function of cones is only mildly affected. In people with the incomplete form of the condition (resulting from CACNA1F mutations), rods and cones are both affected, although they retain some ability to detect light.

Related Gene(s)

Changes in these genes are associated with X-linked congenital stationary night blindness.

  • CACNA1F
  • NYX

How do people inherit X-linked congenital stationary night blindness?

This condition is inherited in an X-linked recessive pattern. The NYX and CACNA1F genes are located on the X chromosome, which is one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. In females (who have two X chromosomes), a mutation would have to occur in both copies of the gene to cause the disorder. Because it is unlikely that females will have two altered copies of this gene, males are affected by X-linked recessive disorders much more frequently than females. A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons.

In X-linked recessive inheritance, a female with one altered copy of the gene in each cell is called a carrier. Carriers of an NYX or CACNA1F mutation can pass on the mutated gene, but most do not develop any of the vision problems associated with X-linked congenital stationary night blindness. However, carriers may have retinal changes that can be detected with an electroretinogram.

Where can I find information about diagnosis or management of X-linked congenital stationary night blindness?

These resources address the diagnosis or management of X-linked congenital stationary night blindness and may include treatment providers.

  • American Optometric Association: Infant Vision (http://www.aoa.org/patients-and-public/good-vision-throughout-life/childrens-vision/infant-vision-birth-to-24-months-of-age)
  • Gene Review: X-Linked Congenital Stationary Night Blindness (http://www.ncbi.nlm.nih.gov/books/NBK1245)
  • Genetic Testing Registry: Congenital stationary night blindness (http://www.ncbi.nlm.nih.gov/gtr/conditions/C0339535)
  • Genetic Testing Registry: Congenital stationary night blindness, type 1A (http://www.ncbi.nlm.nih.gov/gtr/conditions/C1839601)
  • Genetic Testing Registry: Congenital stationary night blindness, type 2A (http://www.ncbi.nlm.nih.gov/gtr/conditions/C1848172)
  • MedlinePlus Encyclopedia: Electroretinography (http://www.nlm.nih.gov/medlineplus/ency/article/003388.htm)
  • MedlinePlus Encyclopedia: Eye movements - Uncontrollable (http://www.nlm.nih.gov/medlineplus/ency/article/003037.htm)
  • MedlinePlus Encyclopedia: Nearsightedness (http://www.nlm.nih.gov/medlineplus/ency/article/001023.htm)
  • MedlinePlus Encyclopedia: Strabismus (http://www.nlm.nih.gov/medlineplus/ency/article/001004.htm)
  • MedlinePlus Encyclopedia: Vision - Night Blindness (http://www.nlm.nih.gov/medlineplus/ency/article/003039.htm)

You might also find information on the diagnosis or management of X-linked congenital stationary night blindness in Educational resources (http://www.ghr.nlm.nih.gov/condition/x-linked-congenital-stationary-night-blindness/show/Educational+resources) and Patient support (http://www.ghr.nlm.nih.gov/condition/x-linked-congenital-stationary-night-blindness/show/Patient+support).

General information about the diagnosis (http://ghr.nlm.nih.gov/handbook/consult/diagnosis) and management (http://ghr.nlm.nih.gov/handbook/consult/treatment) of genetic conditions is available in the Handbook. Read more about genetic testing (http://ghr.nlm.nih.gov/handbook/testing), particularly the difference between clinical tests and research tests (http://ghr.nlm.nih.gov/handbook/testing/researchtesting).

To locate a healthcare provider, see How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

Where can I find additional information about X-linked congenital stationary night blindness?

You may find the following resources about X-linked congenital stationary night blindness helpful. These materials are written for the general public.

You may also be interested in these resources, which are designed for healthcare professionals and researchers.

What other names do people use for X-linked congenital stationary night blindness?

  • XLCSNB
  • X-linked CSNB

For more information about naming genetic conditions, see the Genetics Home Reference Condition Naming Guidelines (http://ghr.nlm.nih.gov/ConditionNameGuide) and How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.

What if I still have specific questions about X-linked congenital stationary night blindness?

Ask the Genetic and Rare Diseases Information Center (http://rarediseases.info.nih.gov/GARD/).

What glossary definitions help with understanding X-linked congenital stationary night blindness?

carrier ; cell ; chromosome ; cones ; congenital ; electroretinogram ; ERG ; gene ; inheritance ; inherited ; involuntary ; mutation ; myopia ; nearsightedness ; nystagmus ; photoreceptor ; prevalence ; recessive ; retina ; rods ; sex chromosomes ; strabismus ; tissue ; visual acuity ; X-linked recessive

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).

References

  • Allen LE, Zito I, Bradshaw K, Patel RJ, Bird AC, Fitzke F, Yates JR, Trump D, Hardcastle AJ, Moore AT. Genotype-phenotype correlation in British families with X linked congenital stationary night blindness. Br J Ophthalmol. 2003 Nov;87(11):1413-20. (http://www.ncbi.nlm.nih.gov/pubmed/14609846?dopt=Abstract)
  • Bech-Hansen NT, Naylor MJ, Maybaum TA, Pearce WG, Koop B, Fishman GA, Mets M, Musarella MA, Boycott KM. Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness. Nat Genet. 1998 Jul;19(3):264-7. (http://www.ncbi.nlm.nih.gov/pubmed/9662400?dopt=Abstract)
  • Bech-Hansen NT, Naylor MJ, Maybaum TA, Sparkes RL, Koop B, Birch DG, Bergen AA, Prinsen CF, Polomeno RC, Gal A, Drack AV, Musarella MA, Jacobson SG, Young RS, Weleber RG. Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness. Nat Genet. 2000 Nov;26(3):319-23. (http://www.ncbi.nlm.nih.gov/pubmed/11062471?dopt=Abstract)
  • Boycott KM, Pearce WG, Bech-Hansen NT. Clinical variability among patients with incomplete X-linked congenital stationary night blindness and a founder mutation in CACNA1F. Can J Ophthalmol. 2000 Jun;35(4):204-13. (http://www.ncbi.nlm.nih.gov/pubmed/10900517?dopt=Abstract)
  • Gene Review: X-Linked Congenital Stationary Night Blindness (http://www.ncbi.nlm.nih.gov/books/NBK1245)
  • Jacobi FK, Andréasson S, Langrova H, Meindl A, Zrenner E, Apfelstedt-Sylla E, Pusch CM. Phenotypic expression of the complete type of X-linked congenital stationary night blindness in patients with different mutations in the NYX gene. Graefes Arch Clin Exp Ophthalmol. 2002 Oct;240(10):822-8. Epub 2002 Sep 21. (http://www.ncbi.nlm.nih.gov/pubmed/12397430?dopt=Abstract)
  • Pusch CM, Zeitz C, Brandau O, Pesch K, Achatz H, Feil S, Scharfe C, Maurer J, Jacobi FK, Pinckers A, Andreasson S, Hardcastle A, Wissinger B, Berger W, Meindl A. The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein. Nat Genet. 2000 Nov;26(3):324-7. (http://www.ncbi.nlm.nih.gov/pubmed/11062472?dopt=Abstract)
  • Strom TM, Nyakatura G, Apfelstedt-Sylla E, Hellebrand H, Lorenz B, Weber BH, Wutz K, Gutwillinger N, Rüther K, Drescher B, Sauer C, Zrenner E, Meitinger T, Rosenthal A, Meindl A. An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness. Nat Genet. 1998 Jul;19(3):260-3. (http://www.ncbi.nlm.nih.gov/pubmed/9662399?dopt=Abstract)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: May 2009
Published: December 16, 2014