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Reviewed April 2007
What is the official name of the ACADSB gene?
The official name of this gene is “acyl-CoA dehydrogenase, short/branched chain.”
ACADSB is the gene's official symbol. The ACADSB gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ACADSB gene?
The ACADSB gene provides instructions for making an enzyme called 2-methylbutyryl-CoA dehydrogenase that plays an important role in processing proteins. Normally, the body breaks down proteins from food into smaller parts called amino acids. Amino acids can be further processed to provide energy for growth and development. In cells throughout the body, 2-methylbutyryl-CoA dehydrogenase is found within specialized structures called mitochondria. Mitochondria convert energy from food to a form that cells can use.
The enzyme 2-methylbutyryl-CoA dehydrogenase helps to process a particular amino acid called isoleucine. Specifically, this enzyme helps with the third step in the breakdown of isoleucine. This step is a chemical reaction that converts a molecule called 2-methylbutyryl-CoA to another molecule, tiglyl-CoA. Additional chemical reactions convert tiglyl-CoA into molecules that are used for energy.
How are changes in the ACADSB gene related to health conditions?
Where is the ACADSB gene located?
Cytogenetic Location: 10q26.13
Molecular Location on chromosome 10: base pairs 124,768,428 to 124,817,805
The ACADSB gene is located on the long (q) arm of chromosome 10 at position 26.13.
More precisely, the ACADSB gene is located from base pair 124,768,428 to base pair 124,817,805 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ACADSB?
You and your healthcare professional may find the following resources about ACADSB helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ACADSB gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ACADSB?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.