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Reviewed January 2013
What is the official name of the ACSF3 gene?
The official name of this gene is “acyl-CoA synthetase family member 3.”
ACSF3 is the gene's official symbol. The ACSF3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ACSF3 gene?
The ACSF3 gene provides instructions for making an enzyme involved in the formation (synthesis) of fatty acids, which are building blocks used to make fats (lipids). The ACSF3 enzyme performs a chemical reaction that converts malonic acid to malonyl-CoA, which is the first step of fatty acid synthesis. Based on this activity, the enzyme is classified as a malonyl-CoA synthetase. The ACSF3 enzyme also converts methylmalonic acid to methylmalonyl-CoA, making it a methylmalonyl-CoA synthetase as well.
Fatty acid synthesis occurs through two pathways, one of which takes place in cellular structures called mitochondria. Mitochondria convert the energy from food into a form that cells can use, and fatty acid synthesis in these structures is thought to be important for their proper functioning. The ACSF3 enzyme is found only in mitochondria and is involved in mitochondrial fatty acid synthesis.
Does the ACSF3 gene share characteristics with other genes?
The ACSF3 gene belongs to a family of genes called ACS (acyl-CoA synthetase family).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ACSF3 gene related to health conditions?
Where is the ACSF3 gene located?
Cytogenetic Location: 16q24.3
Molecular Location on chromosome 16: base pairs 89,160,216 to 89,222,170
The ACSF3 gene is located on the long (q) arm of chromosome 16 at position 24.3.
More precisely, the ACSF3 gene is located from base pair 89,160,216 to base pair 89,222,170 on chromosome 16.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ACSF3?
You and your healthcare professional may find the following resources about ACSF3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ACSF3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ACSF3?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.