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Reviewed October 2008
What is the official name of the ADAMTS13 gene?
The official name of this gene is “ADAM metallopeptidase with thrombospondin type 1 motif, 13.”
ADAMTS13 is the gene's official symbol. The ADAMTS13 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ADAMTS13 gene?
The ADAMTS13 gene provides instructions for making an enzyme that is involved in blood clotting. After an injury, clots normally protect the body by sealing off damaged blood vessels and preventing further blood loss.
The ADAMTS13 enzyme processes a large protein called von Willebrand factor, which also plays a role in clot formation. The unprocessed form of von Willebrand factor interacts easily with cell fragments called platelets, which circulate in the bloodstream and are essential for blood clotting. The factor helps platelets stick together and adhere to the walls of blood vessels, forming temporary clots. The ADAMTS13 enzyme cuts von Willebrand factor into smaller pieces. By processing von Willebrand factor in this way, the enzyme prevents it from triggering the formation of unnecessary blood clots.
Does the ADAMTS13 gene share characteristics with other genes?
The ADAMTS13 gene belongs to a family of genes called ADAMTS (ADAMTS metallopeptidase with thrombospondin type 1 motif family).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ADAMTS13 gene related to health conditions?
Where is the ADAMTS13 gene located?
Cytogenetic Location: 9q34
Molecular Location on chromosome 9: base pairs 136,279,458 to 136,324,524
The ADAMTS13 gene is located on the long (q) arm of chromosome 9 at position 34.
More precisely, the ADAMTS13 gene is located from base pair 136,279,458 to base pair 136,324,524 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ADAMTS13?
You and your healthcare professional may find the following resources about ADAMTS13 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ADAMTS13 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ADAMTS13?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (16 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.