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The information on this page was automatically extracted from online scientific databases.

What is the official name of the AFF3 gene?

The official name of this gene is “AF4/FMR2 family, member 3.”

AFF3 is the gene's official symbol. The AFF3 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the AFF3 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.

How are changes in the AFF3 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the AFF3 gene.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
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Where is the AFF3 gene located?

Cytogenetic Location: 2q11.2-q12

Molecular Location on chromosome 2: base pairs 99,545,863 to 100,142,574

The AFF3 gene is located on the long (q) arm of chromosome 2 between positions 11.2 and 12.

The AFF3 gene is located on the long (q) arm of chromosome 2 between positions 11.2 and 12.

More precisely, the AFF3 gene is located from base pair 99,545,863 to base pair 100,142,574 on chromosome 2.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about AFF3?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the AFF3 gene or gene products?

  • LAF4
  • MLLT2-like

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding AFF3?

DNA ; expressed ; gene ; in vitro ; lymphoid ; protein ; tissue ; transcript ; transcription

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: July 28, 2014