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Reviewed September 2010
What is the official name of the AGL gene?
The official name of this gene is “amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase.”
AGL is the gene's official symbol. The AGL gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the AGL gene?
The AGL gene provides instructions for making the glycogen debranching enzyme. This enzyme is involved in the breakdown of a complex sugar called glycogen, which is a major source of stored energy in the body. Glycogen is made up of several molecules of a simple sugar called glucose. Some glucose molecules are linked together in a straight line, while others branch off and form side chains. The glycogen debranching enzyme is involved in the breakdown of these side chains. The branched structure of glycogen makes it more compact for storage and allows it to break down more easily when it is needed for fuel.
The AGL gene provides instructions for making several different versions (isoforms) of the glycogen debranching enzyme. These isoforms vary by size and are active (expressed) in different tissues.
How are changes in the AGL gene related to health conditions?
Where is the AGL gene located?
Cytogenetic Location: 1p21
Molecular Location on chromosome 1: base pairs 100,315,639 to 100,389,578
The AGL gene is located on the short (p) arm of chromosome 1 at position 21.
More precisely, the AGL gene is located from base pair 100,315,639 to base pair 100,389,578 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about AGL?
You and your healthcare professional may find the following resources about AGL helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the AGL gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding AGL?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.