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Reviewed May 2013
What is the official name of the AGT gene?
The official name of this gene is “angiotensinogen (serpin peptidase inhibitor, clade A, member 8).”
AGT is the gene's official symbol. The AGT gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the AGT gene?
The AGT gene provides instructions for making a protein called angiotensinogen. This protein is part of the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body. In the first step of this process, angiotensinogen is converted to angiotensin I. Through an additional step, angiotensin I is converted to angiotensin II. Angiotensin II causes blood vessels to narrow (constrict), which results in increased blood pressure. This molecule also stimulates production of the hormone aldosterone, which triggers the absorption of salt and water by the kidneys. The increased amount of fluid in the body also increases blood pressure. Proper blood pressure during fetal growth, which delivers oxygen to the developing tissues, is required for normal development of the kidneys, particularly of structures called the proximal tubules, and other tissues. In addition, angiotensin II may play a more direct role in kidney development, perhaps by affecting growth factors involved in the development of kidney structures.
Does the AGT gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the AGT gene related to health conditions?
Where is the AGT gene located?
Cytogenetic Location: 1q42.2
Molecular Location on chromosome 1: base pairs 230,702,522 to 230,714,589
The AGT gene is located on the long (q) arm of chromosome 1 at position 42.2.
More precisely, the AGT gene is located from base pair 230,702,522 to base pair 230,714,589 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about AGT?
You and your healthcare professional may find the following resources about AGT helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the AGT gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding AGT?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.