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Reviewed January 2008
What is the official name of the AGXT gene?
The official name of this gene is “alanine-glyoxylate aminotransferase.”
AGXT is the gene's official symbol. The AGXT gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the AGXT gene?
The AGXT gene provides instructions for making a liver enzyme called alanine-glyoxylate aminotransferase. Inside liver cells, this enzyme is found in peroxisomes, structures that are important for several cellular activities such as ridding the cell of toxic substances and helping to break down certain fats. Peroxisomes contain several enzymes that are imported from the internal fluid of the cell (cytosol). Enzymes that are transferred into peroxisomes have a special arrangement of building blocks (amino acids) at one end of the enzyme that serves as a shipping address. In the peroxisome, alanine-glyoxylate aminotransferase converts a compound called glyoxylate to the amino acid glycine, which is later used for making enzymes and other proteins.
How are changes in the AGXT gene related to health conditions?
Where is the AGXT gene located?
Cytogenetic Location: 2q37.3
Molecular Location on chromosome 2: base pairs 240,868,744 to 240,879,118
The AGXT gene is located on the long (q) arm of chromosome 2 at position 37.3.
More precisely, the AGXT gene is located from base pair 240,868,744 to base pair 240,879,118 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about AGXT?
You and your healthcare professional may find the following resources about AGXT helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the AGXT gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding AGXT?
acids ; alanine ; amino acid ; arginine ; calcium ; cell ; compound ; cytosol ; enzyme ; gene ; glycine ; injury ; kidney ; kidney stones ; leucine ; mitochondria ; mutation ; peroxisomes ; polymorphism ; proline ; serine ; toxic
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.