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AIP

AIP

Reviewed August 2013

What is the official name of the AIP gene?

The official name of this gene is “aryl hydrocarbon receptor interacting protein.”

AIP is the gene's official symbol. The AIP gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the AIP gene?

The AIP gene provides instructions for making a protein called aryl hydrocarbon receptor-interacting protein (AIP). Although AIP's function is not well understood, it is known to interact with numerous other proteins, including one called the aryl hydrocarbon receptor. Through these interactions, AIP likely helps regulate certain cell processes, such as the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), and cell survival. This protein is thought to act as a tumor suppressor, which means it normally helps prevent cells from proliferating in an uncontrolled way.

How are changes in the AIP gene related to health conditions?

familial isolated pituitary adenoma - caused by mutations in the AIP gene

Mutations in the AIP gene cause 15 to 25 percent of cases of familial isolated pituitary adenoma (FIPA), an inherited condition characterized by development of a noncancerous tumor in the pituitary gland (called a pituitary adenoma). This small gland at the base of the brain produces hormones that control many important body functions. There are several types of pituitary adenomas categorized by the hormone they produce. Affected individuals within the same family may develop the same type of pituitary adenoma or different types. People with a mutation in the AIP gene most commonly develop a type of pituitary adenoma called a somatotropinoma. FIPA tumors caused by AIP gene mutations usually occur at a younger age and are larger than those without AIP gene mutations.

Many kinds of mutations in the AIP gene have been identified in affected families. Some of these changes lead to an abnormally short protein or no protein at all. Other mutations change single protein building blocks (amino acids) in AIP. Although it is unclear how these mutations are involved in tumor development, researchers believe that the alterations disrupt interaction between AIP and one or more other proteins. The ability of AIP to control cell proliferation may be reduced, allowing pituitary cells to grow and divide unchecked and form a tumor. It is not known why the pituitary gland is specifically affected or why certain types of pituitary adenomas develop.

Even before FIPA was defined as a condition, doctors recognized that somatotropinomas could occur in multiple members of a family. They referred to these tumors as isolated familial somatotropinoma. These tumors produce and release excess growth hormone (also called somatotropin), which promotes growth of the body. Because it can cause overgrowth of the hands, feet, and face (acromegaly), the condition is also referred to as familial isolated acromegaly. Later, researchers discovered that isolated familial somatotropinoma can be caused by mutations in the AIP gene, and these tumors are now considered part of FIPA.

other disorders - caused by mutations in the AIP gene

Mutations in the AIP gene are found in a small percentage of individuals with sporadic macroadenomas, which are large (macro-) pituitary adenomas that occur in individuals with no history of the condition in their family. When caused by AIP gene mutations, the tumors occur at a relatively young age, usually before age 30. Although other family members are not affected, the gene mutation is often inherited from a parent who never developed an adenoma.

Where is the AIP gene located?

Cytogenetic Location: 11q13.3

Molecular Location on chromosome 11: base pairs 67,483,033 to 67,491,107

The AIP gene is located on the long (q) arm of chromosome 11 at position 13.3.

The AIP gene is located on the long (q) arm of chromosome 11 at position 13.3.

More precisely, the AIP gene is located from base pair 67,483,033 to base pair 67,491,107 on chromosome 11.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about AIP?

You and your healthcare professional may find the following resources about AIP helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the AIP gene or gene products?

  • AH receptor-interacting protein
  • AIP_HUMAN
  • ARA9
  • FKBP16
  • FKBP37
  • HBV X-associated protein 2
  • immunophilin homolog ARA9
  • SMTPHN
  • XAP2
  • XAP-2

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding AIP?

acids ; adenoma ; cell ; cell proliferation ; differentiation ; familial ; gene ; growth hormone ; hormone ; mutation ; pituitary gland ; proliferating ; proliferation ; protein ; receptor ; somatotropin ; sporadic ; tumor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (10 links)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Reviewed: August 2013
Published: April 17, 2014