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Reviewed June 2012
What is the official name of the AKT1 gene?
The official name of this gene is “v-akt murine thymoma viral oncogene homolog 1.”
AKT1 is the gene's official symbol. The AKT1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the AKT1 gene?
The AKT1 gene provides instructions for making a protein called AKT1 kinase. This protein is found in various cell types throughout the body, where it plays a critical role in many signaling pathways. For example, AKT1 kinase helps regulate cell growth and division (proliferation), the process by which cells mature to carry out specific functions (differentiation), and cell survival. AKT1 kinase also helps control apoptosis, which is the self-destruction of cells when they become damaged or are no longer needed.
Signaling involving AKT1 kinase appears to be essential for the normal development and function of the nervous system. Studies have suggested a role for AKT1 kinase in cell-to-cell communication among nerve cells (neurons), neuronal survival, and the formation of memories.
The AKT1 gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous.
How are changes in the AKT1 gene related to health conditions?
Where is the AKT1 gene located?
Cytogenetic Location: 14q32.32
Molecular Location on chromosome 14: base pairs 105,235,685 to 105,262,079
The AKT1 gene is located on the long (q) arm of chromosome 14 at position 32.32.
More precisely, the AKT1 gene is located from base pair 105,235,685 to base pair 105,262,079 on chromosome 14.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about AKT1?
You and your healthcare professional may find the following resources about AKT1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the AKT1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding AKT1?
amino acid ; apoptosis ; cancer ; cell ; cell proliferation ; class ; colorectal ; differentiation ; DNA ; gene ; kinase ; mosaicism ; mutation ; nervous system ; oncogene ; ovarian ; proliferation ; protein ; proto-oncogene ; psychiatric disorder ; schizophrenia ; serine ; syndrome ; threonine ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.