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Reviewed June 2011
What is the official name of the ALDOB gene?
The official name of this gene is “aldolase B, fructose-bisphosphate.”
ALDOB is the gene's official symbol. The ALDOB gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ALDOB gene?
The ALDOB gene provides instructions for making the aldolase B enzyme. This enzyme is one of a group of three aldolase enzymes that are responsible for breaking down certain molecules in cells throughout the body. Four identical aldolase B enzymes need to be attached (bound) to each other in a four-enzyme unit called a tetramer to work.
Aldolase B is found primarily in the liver, but it is also present at lower levels in kidney and intestinal cells. Aldolase B is involved in the breakdown (metabolism) of the simple sugar fructose, which is found mostly in fruits and is used in the body for energy. Aldolase B is responsible for the second step in the metabolism of fructose, which breaks down the molecule fructose-1-phosphate into glyceraldehyde and dihydroxyacetone phosphate. To a lesser degree, aldolase B is also involved in the breakdown of the simple sugar glucose.
The metabolism of fructose is not only essential for the body to use this sugar as energy, but the molecules produced from its breakdown are also needed in the body. The breakdown of dihydroxyacetone phosphate releases a phosphate group (a cluster of oxygen and phosphorus atoms) from this molecule. These phosphate groups are eventually re-used for a number of cell processes, including in the production of adenosine triphosphate (ATP), the cell's main energy source, and the release of stored sugar in the liver.
How are changes in the ALDOB gene related to health conditions?
Where is the ALDOB gene located?
Cytogenetic Location: 9q21.3-q22.2
Molecular Location on chromosome 9: base pairs 104,182,841 to 104,198,061
The ALDOB gene is located on the long (q) arm of chromosome 9 between positions 21.3 and 22.2.
More precisely, the ALDOB gene is located from base pair 104,182,841 to base pair 104,198,061 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ALDOB?
You and your healthcare professional may find the following resources about ALDOB helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ALDOB gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ALDOB?
acids ; adenosine triphosphate ; amino acid ; ATP ; cell ; enzyme ; gene ; glucose ; hypoglycemia ; kidney ; metabolism ; molecule ; mutation ; oxygen ; phosphate ; phosphorus ; protein ; simple sugar ; toxic
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.