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Reviewed March 2011
What is the official name of the AMH gene?
The official name of this gene is “anti-Mullerian hormone.”
AMH is the gene's official symbol. The AMH gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the AMH gene?
The AMH gene provides instructions for making a protein that is involved in male sex differentiation. During development of male fetuses, the AMH protein is produced and released (secreted) by cells of the testes. The secreted protein attaches (binds) to its receptor, which is found on the surface of Müllerian duct cells. The Müllerian duct, found in both male and female fetuses, is the precursor to the female reproductive organs. Binding of the AMH protein to its receptor induces self-destruction (apoptosis) of the Müllerian duct cells. As a result, the Müllerian duct breaks down (regresses) in males. In females, who do not produce the AMH protein during fetal development, the Müllerian duct becomes the uterus and fallopian tubes.
How are changes in the AMH gene related to health conditions?
Where is the AMH gene located?
Cytogenetic Location: 19p13.3
Molecular Location on chromosome 19: base pairs 2,249,113 to 2,252,072
The AMH gene is located on the short (p) arm of chromosome 19 at position 13.3.
More precisely, the AMH gene is located from base pair 2,249,113 to base pair 2,252,072 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about AMH?
You and your healthcare professional may find the following resources about AMH helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the AMH gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding AMH?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.