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Reviewed April 2007
What is the official name of the AMT gene?
The official name of this gene is “aminomethyltransferase.”
AMT is the gene's official symbol. The AMT gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the AMT gene?
The AMT gene provides instructions for making an enzyme called aminomethyltransferase. This enzyme is one of four components (subunits) that make up a large complex called glycine cleavage enzyme. Within cells, this complex is active in specialized energy-producing centers called mitochondria.
As its name suggests, glycine cleavage enzyme processes a molecule called glycine by cutting (cleaving) it into smaller pieces. Glycine is an amino acid, which is a building block of proteins. This molecule also acts as a neurotransmitter, which is a chemical messenger that transmits signals in the brain. The breakdown of excess glycine is necessary for the normal development and function of nerve cells in the brain and spinal cord.
How are changes in the AMT gene related to health conditions?
Where is the AMT gene located?
Cytogenetic Location: 3p21.2-p21.1
Molecular Location on chromosome 3: base pairs 49,416,777 to 49,422,677
The AMT gene is located on the short (p) arm of chromosome 3 between positions 21.2 and 21.1.
More precisely, the AMT gene is located from base pair 49,416,777 to base pair 49,422,677 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about AMT?
You and your healthcare professional may find the following resources about AMT helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the AMT gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding AMT?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.