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Reviewed October 2010
What is the official name of the ANK1 gene?
The official name of this gene is “ankyrin 1, erythrocytic.”
ANK1 is the gene's official symbol. The ANK1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ANK1 gene?
The ANK1 gene provides instruction for making a protein called ankyrin-1. This protein is primarily active (expressed) in red blood cells, but it is also found in muscle and brain cells. In red blood cells, ankyrin-1 is located at the cell membrane, where it attaches (binds) to other membrane proteins. The binding of membrane proteins to one another maintains the stability and structure of red blood cells but also allows for their flexibility. The proteins allow the cell to change shape without breaking when passing through narrow blood vessels.
In muscle and brain cells, ankyrin-1 performs similar functions, binding to other membrane proteins to play a role in cell stability, cell movement, and other cell functions.
How are changes in the ANK1 gene related to health conditions?
Where is the ANK1 gene located?
Cytogenetic Location: 8p11.1
Molecular Location on chromosome 8: base pairs 41,510,743 to 41,754,279
The ANK1 gene is located on the short (p) arm of chromosome 8 at position 11.1.
More precisely, the ANK1 gene is located from base pair 41,510,743 to base pair 41,754,279 on chromosome 8.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ANK1?
You and your healthcare professional may find the following resources about ANK1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ANK1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ANK1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.