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Reviewed April 2006
What is the official name of the ANK2 gene?
The official name of this gene is “ankyrin 2, neuronal.”
ANK2 is the gene's official symbol. The ANK2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ANK2 gene?
The ANK2 gene provides instructions for making a protein called ankyrin-2. Ankyrin-2 is part of a larger family of ankyrins, which interact with many other types of proteins in cells throughout the body. Ankyrins ensure that certain proteins are inserted into the correct locations in the cell membrane and are anchored to the cell's structural framework (the cytoskeleton). Ankyrins play key roles in important cellular functions including movement, growth, and division.
The ankyrin-2 protein is active in many cell types, particularly in the brain and in heart (cardiac) muscle. This protein mainly targets ion channels, which are complexes of proteins that transport charged atoms (ions) across cell membranes. In the heart, the flow of ions (such as sodium, potassium, and calcium) through ion channels is critical for signaling the heart to beat and for maintaining a normal heart rhythm. Ankyrin-2 inserts these channels into their proper locations in the cell membrane so they can regulate the flow of ions into and out of cardiac muscle cells.
How are changes in the ANK2 gene related to health conditions?
Where is the ANK2 gene located?
Cytogenetic Location: 4q25-q27
Molecular Location on chromosome 4: base pairs 113,739,238 to 114,304,895
The ANK2 gene is located on the long (q) arm of chromosome 4 between positions 25 and 27.
More precisely, the ANK2 gene is located from base pair 113,739,238 to base pair 114,304,895 on chromosome 4.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ANK2?
You and your healthcare professional may find the following resources about ANK2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ANK2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ANK2?
amino acid ; arrhythmia ; bradycardia ; calcium ; cardiac ; cell ; cell membrane ; critical region ; cytoskeleton ; fainting ; gene ; ions ; long QT syndrome ; migraine ; pacemaker ; potassium ; protein ; sinoatrial node ; sodium ; syncope ; syndrome
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.