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The official name of this gene is “argininosuccinate lyase.”
ASL is the gene's official symbol. The ASL gene is also known by other names, listed below.
The ASL gene provides instructions for making the protein argininosuccinate lyase. This enzyme participates in the urea cycle, a series of reactions that occur in liver cells. The urea cycle processes excess nitrogen, generated when protein is used by the body, to make a compound called urea that is excreted by the kidneys. Excreting the excess nitrogen prevents it from accumulating in the form of ammonia.
The specific role of the ASL enzyme is to start the reaction in which the amino acid arginine, a building block of proteins, is produced from argininosuccinate, the molecule that carries the waste nitrogen collected earlier in the urea cycle. The arginine is later broken down into urea, which is excreted, and ornithine, which restarts the urea cycle.
More than 30 different mutations in the ASL gene have been identified worldwide. In some cases, a short sequence of DNA is deleted from the gene. Other mutations replace one protein building block (amino acid) with another amino acid in the argininosuccinate lyase enzyme. In people of Arab descent, two common mutations replace the amino acid glutamine with a premature stop signal at position 116 (written as Gln116Ter or Q116X) or position 354 (written as Gln354Ter or Q354X) in the argininosuccinate lyase enzyme. Mutations in the ASL gene may result in an argininosuccinate lyase enzyme that is unstable or the wrong shape.
The shape of an enzyme affects its ability to control a chemical reaction. If the argininosuccinate lyase enzyme is misshapen or missing, it cannot fulfill its role in the urea cycle. Excess nitrogen is not converted to urea for excretion, and ammonia accumulates in the body. Ammonia is toxic, especially to the nervous system, so this accumulation causes neurological problems and other signs and symptoms of argininosuccinic aciduria.
Cytogenetic Location: 7q11.21
Molecular Location on chromosome 7: base pairs 66,075,788 to 66,093,342
The ASL gene is located on the long (q) arm of chromosome 7 at position 11.21.
More precisely, the ASL gene is located from base pair 66,075,788 to base pair 66,093,342 on chromosome 7.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You and your healthcare professional may find the following resources about ASL helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
aciduria ; amino acid ; ammonia ; arginine ; compound ; DNA ; enzyme ; excretion ; gene ; glutamine ; molecule ; nervous system ; neurological ; protein ; toxic ; urea
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.