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Reviewed January 2013
What is the official name of the ATM gene?
The official name of this gene is “ataxia telangiectasia mutated.”
ATM is the gene's official symbol. The ATM gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ATM gene?
The ATM gene provides instructions for making a protein that is located primarily in the nucleus of cells, where it helps control the rate at which cells grow and divide. This protein also plays an important role in the normal development and activity of several body systems, including the nervous system and the immune system. Additionally, the ATM protein assists cells in recognizing damaged or broken DNA strands. DNA can be damaged by agents such as toxic chemicals or radiation. Breaks in DNA strands also occur naturally when chromosomes exchange genetic material during cell division. The ATM protein coordinates DNA repair by activating enzymes that fix the broken strands. Efficient repair of damaged DNA strands helps maintain the stability of the cell's genetic information.
Because of its central role in cell division and DNA repair, the ATM protein is of great interest in cancer research.
How are changes in the ATM gene related to health conditions?
Where is the ATM gene located?
Cytogenetic Location: 11q22-q23
Molecular Location on chromosome 11: base pairs 108,093,558 to 108,239,828
The ATM gene is located on the long (q) arm of chromosome 11 between positions 22 and 23.
More precisely, the ATM gene is located from base pair 108,093,558 to base pair 108,239,828 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ATM?
You and your healthcare professional may find the following resources about ATM helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ATM gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ATM?
ataxia ; cancer ; cell ; cell division ; cerebellum ; deletion ; DNA ; DNA damage ; DNA repair ; gene ; gene deletion ; immune system ; kinase ; mutation ; nervous system ; nucleus ; pancreas ; population ; protein ; radiation ; serine ; stomach ; telangiectasia ; toxic
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (18 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.