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Reviewed August 2007
What is the official name of the BRIP1 gene?
The official name of this gene is “BRCA1 interacting protein C-terminal helicase 1.”
BRIP1 is the gene's official symbol. The BRIP1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the BRIP1 gene?
The BRIP1 gene provides instructions for making a protein that is involved in repairing damaged DNA. Within the nucleus of cells, the BRIP1 protein interacts with the protein produced from the BRCA1 gene. These two proteins work together to mend broken strands of DNA, which prevents cells from accumulating genetic damage that can trigger them to divide uncontrollably. Because BRIP1 and BRCA1 help control the rate of cell growth and division, these proteins are described as tumor suppressors.
DNA is arranged in two long strands that form a spiral called a double helix. The BRIP1 protein acts as a helicase, which means that it attaches to particular regions of DNA and temporarily separates the two strands. By unwinding the strands near sites of DNA damage, the BRIP1 protein allows other proteins (such as BRCA1) to reach damaged areas and fix them. Breaks in DNA can be caused by natural and medical radiation or other environmental exposures, and also occur when chromosomes exchange genetic material in preparation for cell division. By helping repair mistakes in DNA, the BRIP1 protein plays a role in maintaining the stability of a cell's genetic information.
Does the BRIP1 gene share characteristics with other genes?
The BRIP1 gene belongs to a family of genes called FANC (Fanconi anemia, complementation groups).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the BRIP1 gene related to health conditions?
Genetics Home Reference provides information about Fanconi anemia, which is also associated with changes in the BRIP1 gene.
Where is the BRIP1 gene located?
Cytogenetic Location: 17q22.2
Molecular Location on chromosome 17: base pairs 59,756,546 to 59,940,919
The BRIP1 gene is located on the long (q) arm of chromosome 17 at position 22.2.
More precisely, the BRIP1 gene is located from base pair 59,756,546 to base pair 59,940,919 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about BRIP1?
You and your healthcare professional may find the following resources about BRIP1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the BRIP1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding BRIP1?
amino acid ; anemia ; ATP ; blood platelets ; bone marrow ; cancer ; cell ; cell division ; DNA ; DNA damage ; double helix ; gene ; helicase ; nucleus ; platelets ; protein ; radiation ; RNA ; tissue ; tumor ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.