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CCL21

CCL21

The information on this page was automatically extracted from online scientific databases.

What is the official name of the CCL21 gene?

The official name of this gene is “chemokine (C-C motif) ligand 21.”

CCL21 is the gene's official symbol. The CCL21 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the CCL21 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, May 2013]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

How are changes in the CCL21 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the CCL21 gene.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic

Where is the CCL21 gene located?

Cytogenetic Location: 9p13

Molecular Location on chromosome 9: base pairs 34,709,004 to 34,710,166

The CCL21 gene is located on the short (p) arm of chromosome 9 at position 13.

The CCL21 gene is located on the short (p) arm of chromosome 9 at position 13.

More precisely, the CCL21 gene is located from base pair 34,709,004 to base pair 34,710,166 on chromosome 9.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about CCL21?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the CCL21 gene or gene products?

  • 6Ckine
  • CKb9
  • ECL
  • SCYA21
  • SLC
  • TCA4

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding CCL21?

atypical ; B-cells ; chromosome ; cytokine ; expressed ; gene ; in vitro ; ligand ; lymphoid ; mediating ; neutrophils ; protein ; receptor ; T-cells

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: September 15, 2014