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CD2

CD2

The information on this page was automatically extracted from online scientific databases.

What is the official name of the CD2 gene?

The official name of this gene is “CD2 molecule.”

CD2 is the gene's official symbol. The CD2 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the CD2 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]

From UniProtThis link leads to a site outside Genetics Home Reference.:

CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

How are changes in the CD2 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the CD2 gene.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic

Where is the CD2 gene located?

Cytogenetic Location: 1p13.1

Molecular Location on chromosome 1: base pairs 116,754,434 to 116,769,228

The CD2 gene is located on the short (p) arm of chromosome 1 at position 13.1.

The CD2 gene is located on the short (p) arm of chromosome 1 at position 13.1.

More precisely, the CD2 gene is located from base pair 116,754,434 to base pair 116,769,228 on chromosome 1.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about CD2?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the CD2 gene or gene products?

  • LFA-2
  • SRBC
  • T11

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding CD2?

cell ; domain ; erythrocyte ; expressed ; killer cells ; lineage ; lymphocyte ; mediate ; monoclonal ; natural killer cells ; peripheral ; receptor ; T-cells ; T-lymphocyte

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: July 28, 2014