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CD58

CD58

The information on this page was automatically extracted from online scientific databases.

What is the official name of the CD58 gene?

The official name of this gene is “CD58 molecule.”

CD58 is the gene's official symbol. The CD58 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the CD58 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.

How are changes in the CD58 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the CD58 gene.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic

Where is the CD58 gene located?

Cytogenetic Location: 1p13

Molecular Location on chromosome 1: base pairs 116,514,533 to 116,571,092

The CD58 gene is located on the short (p) arm of chromosome 1 at position 13.

The CD58 gene is located on the short (p) arm of chromosome 1 at position 13.

More precisely, the CD58 gene is located from base pair 116,514,533 to base pair 116,571,092 on chromosome 1.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about CD58?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the CD58 gene or gene products?

  • ag3
  • LFA3
  • LFA-3

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding CD58?

epithelial ; gene ; immunoglobulin ; ligand ; lymphocyte ; mediating ; plasma membrane ; protein ; T-lymphocyte ; transcript

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: July 7, 2014