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Reviewed August 2007
What is the official name of the CDH1 gene?
The official name of this gene is “cadherin 1, type 1, E-cadherin (epithelial).”
CDH1 is the gene's official symbol. The CDH1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CDH1 gene?
The CDH1 gene provides instructions for making a protein called epithelial cadherin or E-cadherin. Cadherins are a group of proteins on the surface of cells that help neighboring cells stick to one another (cell adhesion). These proteins bind cells together to form organized tissues.
E-cadherin is one of the best-understood cadherin proteins. In addition to its role in cell adhesion, E-cadherin is involved in transmitting chemical signals within cells, controlling cell movement, and regulating the activity of certain genes. Researchers believe that E-cadherin also acts as a tumor suppressor gene, preventing cells from growing and dividing in an uncontrolled way to form a cancerous tumor. Because this protein helps cells stick together, it may keep cancer cells from detaching from a tumor, traveling through the bloodstream, and invading other tissues (metastasizing).
Does the CDH1 gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the CDH1 gene related to health conditions?
Where is the CDH1 gene located?
Cytogenetic Location: 16q22.1
Molecular Location on chromosome 16: base pairs 68,771,194 to 68,869,443
The CDH1 gene is located on the long (q) arm of chromosome 16 at position 22.1.
More precisely, the CDH1 gene is located from base pair 68,771,194 to base pair 68,869,443 on chromosome 16.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CDH1?
You and your healthcare professional may find the following resources about CDH1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CDH1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CDH1?
adhesion molecule ; calcium ; cancer ; cell ; cell adhesion ; DNA ; epithelial ; family history ; gastric ; gene ; metastasize ; molecule ; promoter ; protein ; stomach ; syndrome ; tumor ; tumor suppressor gene
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.