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Reviewed February 2011
What is the official name of the CFHR5 gene?
The official name of this gene is “complement factor H-related 5.”
CFHR5 is the gene's official symbol. The CFHR5 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CFHR5 gene?
The CFHR5 gene provides instructions for making a protein called complement factor H-related 5. The precise function of this protein is unknown. However, its structure is similar to that of a protein called complement factor H (which is produced from the CFH gene). This similarity provides clues to the probable function of complement factor H-related 5.
Complement factor H regulates a part of the body's immune response known as the complement system. The complement system is a group of proteins that work together to destroy foreign invaders (such as bacteria and viruses), trigger inflammation, and remove debris from cells and tissues. This system must be carefully regulated so it targets only unwanted materials and does not attack the body's healthy cells. Complement factor H helps to protect healthy cells by preventing activation of the complement system when it is not needed. Studies suggest that complement factor H-related 5 probably plays a related role in controlling the complement system.
Does the CFHR5 gene share characteristics with other genes?
The CFHR5 gene belongs to a family of genes called complement (complement system genes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the CFHR5 gene related to health conditions?
Genetics Home Reference provides information about these additional conditions, which are also associated with changes in the CFHR5 gene:
Where is the CFHR5 gene located?
Cytogenetic Location: 1q31.3
Molecular Location on chromosome 1: base pairs 196,946,666 to 196,978,803
The CFHR5 gene is located on the long (q) arm of chromosome 1 at position 31.3.
More precisely, the CFHR5 gene is located from base pair 196,946,666 to base pair 196,978,803 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CFHR5?
You and your healthcare professional may find the following resources about CFHR5 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CFHR5 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CFHR5?
acids ; atypical ; bacteria ; cancer ; chronic ; duplication ; end-stage renal disease ; ESRD ; gene ; immune response ; inflammation ; innate immunity ; kidney ; macular degeneration ; mutation ; nephropathy ; protein ; renal ; renal disease ; stage ; syndrome
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.