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Reviewed September 2010
What is the official name of the CFI gene?
The official name of this gene is “complement factor I.”
CFI is the gene's official symbol. The CFI gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CFI gene?
The CFI gene provides instructions for making a protein called complement factor I. This protein helps regulate a part of the body's immune response known as the complement system. The complement system is a group of proteins that work together to destroy foreign invaders (such as bacteria and viruses), trigger inflammation, and remove debris from cells and tissues. This system must be carefully regulated so it targets only unwanted materials and does not attack the body's healthy cells. Complement factor I and several related proteins protect healthy cells by preventing activation of the complement system when it is not needed.
Does the CFI gene share characteristics with other genes?
The CFI gene belongs to a family of genes called complement (complement system genes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the CFI gene related to health conditions?
Genetics Home Reference provides information about these additional conditions, which are also associated with changes in the CFI gene:
Where is the CFI gene located?
Cytogenetic Location: 4q25
Molecular Location on chromosome 4: base pairs 110,661,847 to 110,723,380
The CFI gene is located on the long (q) arm of chromosome 4 at position 25.
More precisely, the CFI gene is located from base pair 110,661,847 to base pair 110,723,380 on chromosome 4.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CFI?
You and your healthcare professional may find the following resources about CFI helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CFI gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CFI?
atypical ; autoimmune ; bacteria ; deficiency ; expressed ; gene ; immune response ; immune system ; inflammation ; kidney ; macular degeneration ; polymorphism ; protein ; proteinuria ; retina ; syndrome ; visual acuity
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.