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Reviewed November 2011
What is the official name of the CHRNG gene?
The official name of this gene is “cholinergic receptor, nicotinic, gamma (muscle).”
CHRNG is the gene's official symbol. The CHRNG gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CHRNG gene?
The CHRNG gene provides instructions for making the gamma (γ) protein component (subunit) of the acetylcholine receptor (AChR) protein. The AChR protein is found in the membrane of skeletal muscle cells and is critical for signaling between nerve and muscle cells. Signaling between these cells is necessary for movement. The AChR protein consists of five subunits, each of which is produced from a different gene. The subunits are assembled into the AChR protein in the endoplasmic reticulum, a cell structure involved in protein processing and transport, before being transported to the cell membrane. The γ subunit is found only in the fetal AChR protein. At about the thirty-third week of pregnancy, the γ subunit is replaced by the epsilon (ε) subunit, which is produced by the CHRNE gene, to form the adult AChR protein.
How are changes in the CHRNG gene related to health conditions?
Where is the CHRNG gene located?
Cytogenetic Location: 2q37.1
Molecular Location on chromosome 2: base pairs 233,404,436 to 233,411,037
The CHRNG gene is located on the long (q) arm of chromosome 2 at position 37.1.
More precisely, the CHRNG gene is located from base pair 233,404,436 to base pair 233,411,037 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CHRNG?
You and your healthcare professional may find the following resources about CHRNG helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CHRNG gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CHRNG?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.