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Reviewed February 2011
What is the official name of the CLCNKB gene?
The official name of this gene is “chloride channel, voltage-sensitive Kb.”
CLCNKB is the gene's official symbol. The CLCNKB gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CLCNKB gene?
The CLCNKB gene belongs to the CLC family of genes, which provide instructions for making chloride channels. These channels, which transport negatively charged chlorine atoms (chloride ions), play a key role in a cell's ability to generate and transmit electrical signals. Some CLC channels regulate the flow of chloride ions across cell membranes, while others transport chloride ions within cells.
The CLCNKB gene provides instructions for making a chloride channel called ClC-Kb. These channels are found predominantly in the kidneys. ClC-Kb is one of several proteins that work together to regulate the movement of ions into and out of kidney cells. The transport of chloride ions by ClC-Kb channels is part of the mechanism by which the kidneys reabsorb salt (sodium chloride or NaCl) from the urine back into the bloodstream. The retention of salt affects the body's fluid levels and helps maintain blood pressure.
ClC-Kb channels are also located in the inner ear, where they play a role in normal hearing.
Does the CLCNKB gene share characteristics with other genes?
The CLCNKB gene belongs to a family of genes called CLCN (chloride channels, voltage-sensitive).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the CLCNKB gene related to health conditions?
Where is the CLCNKB gene located?
Cytogenetic Location: 1p36
Molecular Location on chromosome 1: base pairs 16,370,230 to 16,383,820
The CLCNKB gene is located on the short (p) arm of chromosome 1 at position 36.
More precisely, the CLCNKB gene is located from base pair 16,370,230 to base pair 16,383,820 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CLCNKB?
You and your healthcare professional may find the following resources about CLCNKB helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CLCNKB gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CLCNKB?
acids ; amino acid ; calcium ; cell ; channel ; chloride ; chloride channels ; gene ; hypertension ; ions ; kb ; kidney ; NaCl ; polymorphism ; potassium ; protein ; sensorineural ; serine ; sodium ; sodium chloride ; syndrome ; threonine ; voltage ; wasting
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.