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Reviewed January 2007
What is the official name of the CREBBP gene?
The official name of this gene is “CREB binding protein.”
CREBBP is the gene's official symbol. The CREBBP gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CREBBP gene?
The CREBBP gene provides instructions for making CREB binding protein, which regulates the activity of many genes in tissues throughout the body. This protein plays an essential role in controlling cell growth and division and prompting cells to mature and assume specialized functions (differentiate). Studies in animals suggest that this protein may also be involved in the formation of long-term memories. CREB binding protein appears to be critical for normal development before and after birth.
CREB binding protein carries out its function by activating transcription, the process of making a blueprint of a gene for protein production. Specifically, CREB binding protein connects transcription factors, which are proteins that start the transcription process, with the complex of proteins that carries out transcription. On the basis of this function, CREB binding protein is called a transcriptional coactivator.
Does the CREBBP gene share characteristics with other genes?
The CREBBP gene belongs to a family of genes called chromatin-modifying enzymes (chromatin-modifying enzymes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the CREBBP gene related to health conditions?
Where is the CREBBP gene located?
Cytogenetic Location: 16p13.3
Molecular Location on chromosome 16: base pairs 3,775,054 to 3,930,120
The CREBBP gene is located on the short (p) arm of chromosome 16 at position 13.3.
More precisely, the CREBBP gene is located from base pair 3,775,054 to base pair 3,930,120 on chromosome 16.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CREBBP?
You and your healthcare professional may find the following resources about CREBBP helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CREBBP gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CREBBP?
acute ; acute myeloid leukemia ; AML ; cancer ; cell ; chemotherapy ; chromosome ; chronic ; DNA ; domain ; gene ; histone ; leukemia ; myelodysplastic syndrome ; myelogenous ; myeloid ; ovarian ; progression ; protein ; rearrangement ; syndrome ; transcription ; translocation
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (13 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.