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Reviewed July 2013
What is the official name of the DCX gene?
The official name of this gene is “doublecortin.”
DCX is the gene's official symbol. The DCX gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the DCX gene?
The DCX gene provides instructions for producing a protein called doublecortin. This protein is involved in the movement of nerve cells (neurons) to their proper locations in the developing brain, a process called neuronal migration. Doublecortin attaches (binds) to microtubules, which are rigid, hollow fibers that make up the cell's structural framework (the cytoskeleton). The binding of doublecortin promotes the stability of microtubules. Microtubules help propel neurons by forming scaffolding within the cell that elongates in a specific direction, altering the cytoskeleton and moving the neuron.
How are changes in the DCX gene related to health conditions?
Where is the DCX gene located?
Cytogenetic Location: Xq22.3-q23
Molecular Location on the X chromosome: base pairs 111,293,778 to 111,412,231
The DCX gene is located on the long (q) arm of the X chromosome between positions 22.3 and 23.
More precisely, the DCX gene is located from base pair 111,293,778 to base pair 111,412,231 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about DCX?
You and your healthcare professional may find the following resources about DCX helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the DCX gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding DCX?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.