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Reviewed July 2008
What is the official name of the DCX gene?
The official name of this gene is “doublecortin.”
DCX is the gene's official symbol. The DCX gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the DCX gene?
The DCX gene provides instructions for producing a protein called doublecortin. This protein is involved in the migration of nerve cells (neurons) to their proper location in the developing brain. Doublecortin plays a role in neuronal migration by attaching (binding) to microtubules, which are rigid, hollow fibers that make up the cell's structural framework (the cytoskeleton). In neuronal migration, microtubules help propel the neurons by forming a meshwork around the nucleus of the cell and, with the aid of other proteins, expanding and contracting the cytoskeleton to move the nucleus and whole neuron forward. Doublecortin is involved in the organization of the microtubule structures. Proper microtubule function is necessary for correct neuronal organization in the exterior of the brain (cerebral cortex).
How are changes in the DCX gene related to health conditions?
Where is the DCX gene located?
Cytogenetic Location: Xq22.3-q23
Molecular Location on the X chromosome: base pairs 110,537,006 to 110,655,459
The DCX gene is located on the long (q) arm of the X chromosome between positions 22.3 and 23.
More precisely, the DCX gene is located from base pair 110,537,006 to base pair 110,655,459 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about DCX?
You and your healthcare professional may find the following resources about DCX helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the DCX gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding DCX?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.