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Reviewed November 2010
What is the official name of the DNM2 gene?
The official name of this gene is “dynamin 2.”
DNM2 is the gene's official symbol. The DNM2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the DNM2 gene?
The DNM2 gene provides instructions for making a protein called dynamin 2. Dynamin 2 is present in cells throughout the body. It is involved in endocytosis, a process that brings substances into the cell. During endocytosis, the cell membrane folds around a substance outside the cell (such as a protein) to form a sac-like structure called a vesicle. The vesicle is drawn into the cell and is pinched off from the cell membrane. Dynamin 2 is thought to play a key role in altering the cell membrane to form these vesicles.
Dynamin 2 also associates with tube-like structures, called microtubules, which are part of the cell's structural framework (cytoskeleton). The cytoskeleton defines cell shape, organizes the placement of cell contents, and aids in cell movement. Microtubules are also essential for cell division. In a related role, dynamin 2 appears to be important for the structure of a cell component called the centrosome, which is the organizing center for microtubules.
How are changes in the DNM2 gene related to health conditions?
Where is the DNM2 gene located?
Cytogenetic Location: 19p13.2
Molecular Location on chromosome 19: base pairs 10,828,728 to 10,944,168
The DNM2 gene is located on the short (p) arm of chromosome 19 at position 13.2.
More precisely, the DNM2 gene is located from base pair 10,828,728 to base pair 10,944,168 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about DNM2?
You and your healthcare professional may find the following resources about DNM2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the DNM2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding DNM2?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (15 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.