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The official name of this gene is “dopamine receptor D3.”
DRD3 is the gene's official symbol. The DRD3 gene is also known by other names, listed below.
The DRD3 gene provides instructions for making a protein called dopamine receptor D3, which is found in the brain. This protein responds to the chemical messenger (neurotransmitter) dopamine to trigger signals within the nervous system, including signals involved in producing physical movement.
The DRD3 gene belongs to a family of genes called GPCR (G protein-coupled receptors).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genefamilies) in the Handbook.
Some studies have found the DRD3 gene to be associated with essential tremor. A DRD3 gene variant seen in some families affected by this disorder results in a dopamine receptor D3 protein in which the protein building block (amino acid) serine at position 9 is replaced with the amino acid glycine (written as Ser9Gly or S9G). This variant binds more strongly to dopamine, resulting in a stronger response to the neurotransmitter and possibly causing the involuntary shaking seen in essential tremor.
Cytogenetic Location: 3q13.3
Molecular Location on chromosome 3: base pairs 113,847,556 to 113,897,898
The DRD3 gene is located on the long (q) arm of chromosome 3 at position 13.3.
More precisely, the DRD3 gene is located from base pair 113,847,556 to base pair 113,897,898 on chromosome 3.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You and your healthcare professional may find the following resources about DRD3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
amino acid ; dopamine ; gene ; glycine ; involuntary ; nervous system ; protein ; receptor ; serine ; tremor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.