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Reviewed October 2007
What is the official name of the EIF2B1 gene?
The official name of this gene is “eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa.”
EIF2B1 is the gene's official symbol. The EIF2B1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the EIF2B1 gene?
The EIF2B1 gene provides instructions for making one of five parts of a protein called eIF2B, specifically the alpha subunit of this protein. The eIF2B protein helps regulate overall protein production (synthesis) in the cell by interacting with another protein, eIF2. The eIF2 protein is called an initiation factor because it is involved in starting (initiating) protein synthesis.
Under some conditions, eIF2B increases protein synthesis by helping to recycle molecules called GTP, which carry energy to the initiation factor. Under other conditions, it slows protein synthesis by binding tightly to the initiation factor, which converts the eIF2B protein into an inactive form and prevents recycling of GTP.
Proper regulation of protein synthesis is vital for ensuring that the correct levels of protein are available for the cell to cope with changing conditions. For example, cells must synthesize protein much faster if they are multiplying than if they are in a resting state.
How are changes in the EIF2B1 gene related to health conditions?
Where is the EIF2B1 gene located?
Cytogenetic Location: 12q24.31
Molecular Location on chromosome 12: base pairs 124,105,569 to 124,118,322
The EIF2B1 gene is located on the long (q) arm of chromosome 12 at position 24.31.
More precisely, the EIF2B1 gene is located from base pair 124,105,569 to base pair 124,118,322 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about EIF2B1?
You and your healthcare professional may find the following resources about EIF2B1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the EIF2B1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding EIF2B1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (14 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.