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The official name of this gene is “v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2.”
ERBB2 is the gene's official symbol. The ERBB2 gene is also known by other names, listed below.
The ERBB2 gene is also commonly referred to as Her-2/neu, especially by doctors and other clinicians. This gene is one member of a family of genes that provide instructions for producing growth factor receptors. Growth factors are proteins that stimulate cell growth and division.
The ERBB2 gene provides instructions for making a protein called the ErbB2 growth factor receptor. This receptor is located on the surface of cells, where it associates with similar receptors to form a complex. Growth factors bind to these similar receptors (ErbB3, for example) and trigger the receptor complex to relay signals inside the cell. These signals activate certain genes that promote cell growth. ErbB2 probably also plays a role in connecting cells together (cell adhesion), the process by which cells mature to carry out specific functions (cell specialization), and cell movement.
The ERBB2 gene belongs to a family of genes called CD (CD molecules).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genefamilies) in the Handbook.
Some gene mutations are acquired during a person's lifetime and are present only in certain cells. These changes, which are called somatic mutations, are not inherited. Somatic mutations sometimes occur when DNA makes a copy of itself (replicates) in preparation for cell division. Errors in the replication process can result in multiple copies of a gene on a chromosome. The presence of multiple gene copies, known as gene amplification, can underlie the formation and growth of tumor cells depending on which gene is amplified. For example, amplification of the ERBB2 gene is found in about 25 percent of breast cancers. Extra copies of this gene cause too much of the ErbB2 receptor protein to be made in the cell (overexpression). Excess ErbB2 protein signals cells to grow and divide continuously, which can contribute to the growth of cancerous tumors. Overexpression of ErbB2 is associated with aggressive breast tumors that are more likely to spread to other tissues (metastasize).
Amplification of the ERBB2 gene has been reported in several other types of cancer, including ovarian, brain, stomach, and lung cancers. ERBB2 gene amplification results in overproduction of the ErbB2 protein, which likely stimulates cells to grow and divide continuously. This uncontrolled cell division can lead to the growth and progression of cancerous tumors.
Cytogenetic Location: 17q12
Molecular Location on chromosome 17: base pairs 37,844,166 to 37,884,914
The ERBB2 gene is located on the long (q) arm of chromosome 17 at position 12.
More precisely, the ERBB2 gene is located from base pair 37,844,166 to base pair 37,884,914 on chromosome 17.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You and your healthcare professional may find the following resources about ERBB2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
cancer ; cell ; cell adhesion ; cell division ; chromosome ; DNA ; gene ; gene amplification ; glioblastoma ; growth factor ; kinase ; leukemia ; metastasize ; oncogene ; ovarian ; progression ; protein ; proto-oncogene ; receptor ; stomach ; tumor ; tyrosine
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.