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References

These sources were used to develop the Genetics Home Reference gene summary on the EWSR1 gene.

Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L. EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. Mol Cell Biol. 1998 Mar;18(3):1489-97. PubMed citation
Entrez Gene
Li KK, Lee KA. Transcriptional activation by the Ewing's sarcoma (EWS) oncogene can be cis-repressed by the EWS RNA-binding domain. J Biol Chem. 2000 Jul 28;275(30):23053-8. PubMed citation
May WA, Gishizky ML, Lessnick SL, Lunsford LB, Lewis BC, Delattre O, Zucman J, Thomas G, Denny CT. Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5752-6. PubMed citation
Ohno T, Rao VN, Reddy ES. EWS/Fli-1 chimeric protein is a transcriptional activator. Cancer Res. 1993 Dec 15;53(24):5859-63. PubMed citation
OMIM: EWING SARCOMA BREAKPOINT REGION 1
Osuna D, de Alava E. Molecular pathology of sarcomas. Rev Recent Clin Trials. 2009 Jan;4(1):12-26. Review. PubMed citation
Rossow KL, Janknecht R. The Ewing's sarcoma gene product functions as a transcriptional activator. Cancer Res. 2001 Mar 15;61(6):2690-5. PubMed citation

Reviewed: May 2012

Published: May 13, 2013