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Reviewed April 2009
What is the official name of the F12 gene?
The official name of this gene is “coagulation factor XII (Hageman factor).”
F12 is the gene's official symbol. The F12 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the F12 gene?
The F12 gene provides instructions for making a protein called coagulation factor XII. Coagulation factors are a group of related proteins that are essential for normal blood clotting (coagulation). After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss. Factor XII circulates in the bloodstream in an inactive form until it is activated, usually by coming in contact with damaged blood vessel walls. Upon activation, factor XII interacts with coagulation factor XI. This interaction sets off a chain of additional chemical reactions that form a blood clot.
Factor XII also plays a role in stimulating inflammation, a normal body response to infection, irritation, or other injury. When factor XII is activated, it also interacts with a protein called plasma prekallikrein. This interaction initiates a series of chemical reactions that lead to the release of a protein called bradykinin. Bradykinin promotes inflammation by increasing the permeability of blood vessel walls, allowing more fluids to leak into body tissues. This leakage causes the swelling that accompanies inflammation.
How are changes in the F12 gene related to health conditions?
Where is the F12 gene located?
Cytogenetic Location: 5q33-qter
Molecular Location on chromosome 5: base pairs 176,829,138 to 176,836,576
The F12 gene is located on the long (q) arm of chromosome 5 between position 33 and the end (terminus) of the arm.
More precisely, the F12 gene is located from base pair 176,829,138 to base pair 176,836,576 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about F12?
You and your healthcare professional may find the following resources about F12 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the F12 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding F12?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.