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FCGR2A

FCGR2A

The information on this page was automatically extracted from online scientific databases.

What is the official name of the FCGR2A gene?

The official name of this gene is “Fc fragment of IgG, low affinity IIa, receptor (CD32).”

FCGR2A is the gene's official symbol. The FCGR2A gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the FCGR2A gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

How are changes in the FCGR2A gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the FCGR2A gene.
NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the FCGR2A gene.
  • Susceptibility to malaria[1]This link leads to a site outside Genetics Home Reference.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic
[1]

Where is the FCGR2A gene located?

Cytogenetic Location: 1q23

Molecular Location on chromosome 1: base pairs 161,505,414 to 161,519,569

The FCGR2A gene is located on the long (q) arm of chromosome 1 at position 23.

The FCGR2A gene is located on the long (q) arm of chromosome 1 at position 23.

More precisely, the FCGR2A gene is located from base pair 161,505,414 to base pair 161,519,569 on chromosome 1.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about FCGR2A?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the FCGR2A gene or gene products?

  • CD32
  • CD32A
  • CDw32
  • FCG2
  • FcGR
  • FCGR2
  • FCGR2A1
  • IGFR2

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding FCGR2A?

alternative splicing ; antigens ; cell ; gene ; immune response ; immunoglobulin ; malaria ; neutrophils ; phagocytosis ; protein ; receptor ; soluble ; splicing ; susceptibility ; transcript

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: April 21, 2014