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FGF10

FGF10

Reviewed June 2013

What is the official name of the FGF10 gene?

The official name of this gene is “fibroblast growth factor 10.”

FGF10 is the gene's official symbol. The FGF10 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the FGF10 gene?

The FGF10 gene provides instructions for making a protein called fibroblast growth factor 10 (FGF10). This protein is part of a family of proteins called fibroblast growth factors that are involved in important processes such as cell division, regulation of cell growth and maturation, formation of blood vessels, wound healing, and development before birth. By attaching to another protein known as a receptor, the FGF10 protein triggers a cascade of chemical reactions inside the cell that signals the cell to undergo certain changes, such as maturing to take on specialized functions. During development before birth, the signals triggered by the FGF10 protein appear to stimulate cells to form the structures that make up the ears, skeleton, organs, and glands in the eyes and mouth.

How are changes in the FGF10 gene related to health conditions?

lacrimo-auriculo-dento-digital syndrome - caused by mutations in the FGF10 gene

At least three mutations in the FGF10 gene have been found to cause lacrimo-auriculo-dento-digital (LADD) syndrome. This disorder affects the formation of the lacrimal system (the system in the eyes that produces and secretes tears), the ears, the salivary glands (the glands in the mouth that produce saliva), the teeth, the hands, and sometimes, other parts of the body. The main features of LADD syndrome are abnormal tear production, malformed ears with hearing loss, decreased saliva production, small teeth, and hand deformities.

The FGF10 gene mutations that cause LADD syndrome reduce the amount and activity of FGF10 protein. Less growth factor is available to bind to receptors, which decreases signaling within cells. A decrease in cell signaling disrupts cell maturation and development, which results in abnormal formation of the ears, skeleton, and glands in the eyes and mouth in people with LADD syndrome.

other disorders - caused by mutations in the FGF10 gene

Mutations in the FGF10 gene have also been found to cause a condition similar to LADD syndrome called aplasia of lacrimal and salivary glands (ALSG). Individuals with this condition have absent (aplastic) or small (hypoplastic) lacrimal glands, which secrete tears in the eyes, and aplastic or hypoplastic salivary glands. This condition often causes eye irritability, chronic tearing (epiphora), dry mouth (xerostomia), and a greater susceptibility to cavities. Sometimes, other structures that are involved in tear production are affected. The mutations that cause ALSG are thought to be less disruptive to cell signaling than the FGF10 gene mutations that cause LADD syndrome, although in rare cases, the same mutation can cause either condition. Because there is overlap between the features of ALSG and LADD syndrome and because they are caused by mutations in the same gene, it is difficult to discern whether they are distinct disorders or part of the same disease spectrum.

Where is the FGF10 gene located?

Cytogenetic Location: 5p13-p12

Molecular Location on chromosome 5: base pairs 44,304,901 to 44,389,705

The FGF10 gene is located on the short (p) arm of chromosome 5 between positions 13 and 12.

The FGF10 gene is located on the short (p) arm of chromosome 5 between positions 13 and 12.

More precisely, the FGF10 gene is located from base pair 44,304,901 to base pair 44,389,705 on chromosome 5.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about FGF10?

You and your healthcare professional may find the following resources about FGF10 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the FGF10 gene or gene products?

  • FGF-10
  • FGF10_HUMAN
  • keratinocyte growth factor 2

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding FGF10?

cell ; cell division ; chronic ; fibroblast ; gene ; growth factor ; keratinocyte ; mutation ; protein ; receptor ; spectrum ; susceptibility ; syndrome

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (5 links)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Reviewed: June 2013
Published: December 16, 2014