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Genetics Home Reference: your guide to understanding genetic conditions
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FGFRL1

Reviewed June 2005

What is the official name of the FGFRL1 gene?

The official name of this gene is “fibroblast growth factor receptor-like 1.”

FGFRL1 is the gene's official symbol. The FGFRL1 gene is also known by other names, listed below.

What is the normal function of the FGFRL1 gene?

The FGFRL1 gene produces a protein that is part of a family of fibroblast growth factor receptors that share similar structures and functions. This family of receptors plays a role in important processes such as cell division, cell growth and maturation, formation of blood vessels, wound healing, and embryo development. Proteins in the FGFR family span the cell membrane, so that one end of the protein remains inside the cell (the intracellular portion) and the other end sits on the outer surface of the cell. This positioning of the protein allows it to receive signals from outside the cell that help the cell respond to its environment.

The FGFRL1 protein is considerably shorter than other members of the FGFR family as it lacks a segment of the intracellular portion. Although the role of this receptor protein remains unknown, its structure indicates that it could interact with other FGFR proteins and potentially inhibit cell signaling. FGFRL1 gene activity has been detected in fetal cartilage. This finding indicates that the FGFRL1 gene may be involved in skeletal formation during development.

Does the FGFRL1 gene share characteristics with other genes?

The FGFRL1 gene belongs to a family of genes called immunoglobulin superfamily, I-set domain containing (immunoglobulin superfamily, I-set domain containing).

A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genefamilies) in the Handbook.

Where is the FGFRL1 gene located?

Cytogenetic Location: 4p16

Molecular Location on chromosome 4: base pairs 1,011,821 to 1,026,897

The FGFRL1 gene is located on the short (p) arm of chromosome 4 at position 16.

The FGFRL1 gene is located on the short (p) arm of chromosome 4 at position 16.

More precisely, the FGFRL1 gene is located from base pair 1,011,821 to base pair 1,026,897 on chromosome 4.

See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.

Where can I find additional information about FGFRL1?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the FGFRL1 gene or gene products?

  • FGFR5
  • Fibroblast growth factor receptor 5

See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.

What glossary definitions help with understanding FGFRL1?

cartilage ; cell ; cell division ; cell membrane ; embryo ; fibroblast ; gene ; growth factor ; intracellular ; protein ; receptor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).

References

  • Kim I, Moon S, Yu K, Kim U, Koh GY. A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas(1). Biochim Biophys Acta. 2001 Mar 19;1518(1-2):152-6. (http://www.ncbi.nlm.nih.gov/pubmed/11267671?dopt=Abstract)
  • NCBI Gene (http://www.ncbi.nlm.nih.gov/gene/53834)
  • Trueb B, Zhuang L, Taeschler S, Wiedemann M. Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. J Biol Chem. 2003 Sep 5;278(36):33857-65. Epub 2003 Jun 17. (http://www.ncbi.nlm.nih.gov/pubmed/12813049?dopt=Abstract)
  • Wiedemann M, Trueb B. Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. Genomics. 2000 Oct 15;69(2):275-9. (http://www.ncbi.nlm.nih.gov/pubmed/11031111?dopt=Abstract)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: June 2005
Published: December 22, 2014