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The official name of this gene is “fibroblast growth factor receptor-like 1.”
FGFRL1 is the gene's official symbol. The FGFRL1 gene is also known by other names, listed below.
The FGFRL1 gene produces a protein that is part of a family of fibroblast growth factor receptors that share similar structures and functions. This family of receptors plays a role in important processes such as cell division, cell growth and maturation, formation of blood vessels, wound healing, and embryo development. Proteins in the FGFR family span the cell membrane, so that one end of the protein remains inside the cell (the intracellular portion) and the other end sits on the outer surface of the cell. This positioning of the protein allows it to receive signals from outside the cell that help the cell respond to its environment.
The FGFRL1 protein is considerably shorter than other members of the FGFR family as it lacks a segment of the intracellular portion. Although the role of this receptor protein remains unknown, its structure indicates that it could interact with other FGFR proteins and potentially inhibit cell signaling. FGFRL1 gene activity has been detected in fetal cartilage. This finding indicates that the FGFRL1 gene may be involved in skeletal formation during development.
The FGFRL1 gene belongs to a family of genes called immunoglobulin superfamily, I-set domain containing (immunoglobulin superfamily, I-set domain containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genefamilies) in the Handbook.
Cytogenetic Location: 4p16
Molecular Location on chromosome 4: base pairs 1,004,711 to 1,020,685
The FGFRL1 gene is located on the short (p) arm of chromosome 4 at position 16.
More precisely, the FGFRL1 gene is located from base pair 1,004,711 to base pair 1,020,685 on chromosome 4.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
cartilage ; cell ; cell division ; cell membrane ; embryo ; fibroblast ; gene ; growth factor ; intracellular ; protein ; receptor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://www.ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.