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Reviewed November 2012
What is the official name of the FLCN gene?
The official name of this gene is “folliculin.”
FLCN is the gene's official symbol. The FLCN gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FLCN gene?
The FLCN gene provides instructions for making a protein called folliculin. Researchers have not determined the protein's function, but they believe it may act as a tumor suppressor. Tumor suppressors help control the growth and division of cells.
The folliculin protein is present in many of the body's tissues, including the brain, heart, placenta, testis, skin, lung, and kidney. Researchers have proposed several possible roles for the protein within cells. Folliculin may be important for cells' uptake of foreign particles (endocytosis or phagocytosis). The protein may also play a role in the structural framework that helps to define the shape, size, and movement of a cell (the cytoskeleton) and in interactions between cells. In the lung, it is thought that folliculin plays a role in repairing and re-forming lung tissue following damage.
How are changes in the FLCN gene related to health conditions?
Where is the FLCN gene located?
Cytogenetic Location: 17p11.2
Molecular Location on chromosome 17: base pairs 17,212,208 to 17,237,189
The FLCN gene is located on the short (p) arm of chromosome 17 at position 11.2.
More precisely, the FLCN gene is located from base pair 17,212,208 to base pair 17,237,189 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FLCN?
You and your healthcare professional may find the following resources about FLCN helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FLCN gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FLCN?
acids ; benign ; cancer ; carcinoma ; cell ; colon ; cysts ; cytoskeleton ; endocytosis ; gene ; inflammation ; kidney ; mutation ; phagocytosis ; placenta ; pneumothorax ; protein ; renal ; rupture ; spontaneous ; sporadic ; syndrome ; testis ; tissue ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.