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Reviewed July 2012
What is the official name of the FOXC1 gene?
The official name of this gene is “forkhead box C1.”
FOXC1 is the gene's official symbol. The FOXC1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FOXC1 gene?
The FOXC1 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and regulates the activity of other genes. On the basis of this action, the FOXC1 protein is called a transcription factor.
The FOXC1 protein plays a critical role in early development, particularly in the formation of structures in the front part of the eye (the anterior segment). These structures include the colored part of the eye (the iris), the central hole in the iris through which light enters the eye (the pupil), and the clear front covering of the eye (the cornea). Studies suggest that the FOXC1 protein may also have functions in the adult eye, such as helping cells respond to oxidative stress. Oxidative stress occurs when unstable molecules called free radicals accumulate to levels that can damage or kill cells.
The FOXC1 protein is also involved in the normal development of other parts of the body, including the heart, kidneys, and brain.
Does the FOXC1 gene share characteristics with other genes?
The FOXC1 gene belongs to a family of genes called FOX (forkhead box genes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the FOXC1 gene related to health conditions?
Genetics Home Reference provides information about Dandy-Walker syndrome, which is also associated with changes in the FOXC1 gene.
Where is the FOXC1 gene located?
Cytogenetic Location: 6p25
Molecular Location on chromosome 6: base pairs 1,610,680 to 1,614,131
The FOXC1 gene is located on the short (p) arm of chromosome 6 at position 25.
More precisely, the FOXC1 gene is located from base pair 1,610,680 to base pair 1,614,131 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FOXC1?
You and your healthcare professional may find the following resources about FOXC1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FOXC1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FOXC1?
acids ; anterior ; cerebellum ; chromosome ; cornea ; DNA ; duplication ; free radicals ; gene ; glaucoma ; malformation ; myeloid ; oxidative stress ; protein ; pupil ; stress ; syndrome ; transcription ; transcription factor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.