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Reviewed June 2014
What is the official name of the FRAS1 gene?
The official name of this gene is “Fraser syndrome 1.”
FRAS1 is the gene's official symbol. The FRAS1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FRAS1 gene?
The FRAS1 gene provides instructions for making a protein that is part of a group of proteins called the FRAS/FREM complex. This complex is found in basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. The FRAS/FREM complex is particularly important during development before birth. One of its roles is to anchor the top layer of skin by connecting the basement membrane of the top layer to the layer of skin below. The FRAS/FREM complex is also involved in the proper development of certain other organs and tissues, including the kidneys, although the mechanism is unclear.
How are changes in the FRAS1 gene related to health conditions?
Where is the FRAS1 gene located?
Cytogenetic Location: 4q21.21
Molecular Location on chromosome 4: base pairs 78,056,967 to 78,544,268
The FRAS1 gene is located on the long (q) arm of chromosome 4 at position 21.21.
More precisely, the FRAS1 gene is located from base pair 78,056,967 to base pair 78,544,268 on chromosome 4.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FRAS1?
You and your healthcare professional may find the following resources about FRAS1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FRAS1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FRAS1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.