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Reviewed December 2008
What is the official name of the FUCA1 gene?
The official name of this gene is “fucosidase, alpha-L- 1, tissue.”
FUCA1 is the gene's official symbol. The FUCA1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FUCA1 gene?
The FUCA1 gene provides instructions for making an enzyme called alpha-L-fucosidase. This enzyme is found in lysosomes, which are compartments in the cell that digest and recycle materials. Within lysosomes, this enzyme plays a role in the breakdown of complexes of sugar molecules (oligosaccharides) attached to certain proteins (glycoproteins) and fats (glycolipids). Alpha-L-fucosidase is responsible for cutting (cleaving) off a sugar molecule called fucose toward the end of the breakdown process.
How are changes in the FUCA1 gene related to health conditions?
Where is the FUCA1 gene located?
Cytogenetic Location: 1p34
Molecular Location on chromosome 1: base pairs 24,171,566 to 24,194,858
The FUCA1 gene is located on the short (p) arm of chromosome 1 at position 34.
More precisely, the FUCA1 gene is located from base pair 24,171,566 to base pair 24,194,858 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FUCA1?
You and your healthcare professional may find the following resources about FUCA1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FUCA1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FUCA1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.