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Reviewed August 2012
What is the official name of the FUS gene?
The official name of this gene is “fused in sarcoma.”
FUS is the gene's official symbol. The FUS gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FUS gene?
The FUS gene provides instructions for making a protein called fused in sarcoma (FUS). This protein is found within the cell nucleus in most tissues and is involved in many of the steps of protein production. The FUS protein attaches (binds) to DNA and regulates an activity called transcription, which is the first step in the production of proteins from genes. This protein also helps repair mistakes in DNA, which prevents cells from accumulating genetic damage.
The FUS protein is also involved in processing molecules called messenger RNA (mRNA), which serve as genetic blueprints for making proteins. By cutting and rearranging mRNA molecules in different ways, the FUS protein controls the production of different versions of certain proteins. This process is known as alternative splicing. Once the FUS protein processes the mRNA, it transports the mRNA out of the nucleus where it gets taken up by other cell structures to be further processed into a mature protein.
How are changes in the FUS gene related to health conditions?
Genetics Home Reference provides information about Ewing sarcoma, which is also associated with changes in the FUS gene.
Where is the FUS gene located?
Cytogenetic Location: 16p11.2
Molecular Location on chromosome 16: base pairs 31,180,109 to 31,194,870
The FUS gene is located on the short (p) arm of chromosome 16 at position 11.2.
More precisely, the FUS gene is located from base pair 31,180,109 to base pair 31,194,870 on chromosome 16.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FUS?
You and your healthcare professional may find the following resources about FUS helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FUS gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FUS?
acute ; acute myeloid leukemia ; alternative splicing ; AML ; bone marrow ; cancer ; cartilage ; cell ; cell nucleus ; chromosome ; dementia ; DNA ; gene ; leukemia ; messenger RNA ; mRNA ; mutation ; myeloid ; nerve cell ; nucleus ; oncogene ; protein ; RNA ; sarcoma ; sclerosis ; soft tissue ; somatic mutation ; splicing ; tissue ; transcription ; tumor ; wasting
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.