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Reviewed April 2007
What is the official name of the GLDC gene?
The official name of this gene is “glycine dehydrogenase (decarboxylating).”
GLDC is the gene's official symbol. The GLDC gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the GLDC gene?
The GLDC gene provides instructions for making an enzyme called glycine dehydrogenase. This enzyme is one of four components (subunits) that make up a large complex called glycine cleavage enzyme. Within cells, this complex is active in specialized energy-producing centers called mitochondria.
As its name suggests, glycine cleavage enzyme processes a molecule called glycine by cutting (cleaving) it into smaller pieces. Glycine is an amino acid, which is a building block of proteins. This molecule also acts as a neurotransmitter, which is a chemical messenger that transmits signals in the brain. The breakdown of excess glycine is necessary for the normal development and function of nerve cells in the brain and spinal cord.
How are changes in the GLDC gene related to health conditions?
Where is the GLDC gene located?
Cytogenetic Location: 9p22
Molecular Location on chromosome 9: base pairs 6,532,463 to 6,645,691
The GLDC gene is located on the short (p) arm of chromosome 9 at position 22.
More precisely, the GLDC gene is located from base pair 6,532,463 to base pair 6,645,691 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about GLDC?
You and your healthcare professional may find the following resources about GLDC helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the GLDC gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding GLDC?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.