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Reviewed September 2010
What is the official name of the GRN gene?
The official name of this gene is “granulin.”
GRN is the gene's official symbol. The GRN gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the GRN gene?
The GRN gene provides instructions for making a protein called granulin (also known as progranulin). This protein is found in tissues throughout the body. It is most active in cells that are dividing rapidly, such as skin cells and cells that line the gastrointestinal tract. Granulin helps regulate the growth, division, and survival of these cells. It also plays important roles in early embryonic development, regulation of the body's immune system response, and wound healing.
Granulin is active in several types of brain cells, although much less is known about this protein's function in the brain. It appears to be critical for the survival of nerve cells (neurons).
How are changes in the GRN gene related to health conditions?
Where is the GRN gene located?
Cytogenetic Location: 17q21.32
Molecular Location on chromosome 17: base pairs 42,422,490 to 42,430,473
The GRN gene is located on the long (q) arm of chromosome 17 at position 21.32.
More precisely, the GRN gene is located from base pair 42,422,490 to base pair 42,430,473 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about GRN?
You and your healthcare professional may find the following resources about GRN helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the GRN gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding GRN?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.