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Reviewed August 2010
What is the official name of the GUSB gene?
The official name of this gene is “glucuronidase, beta.”
GUSB is the gene's official symbol. The GUSB gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the GUSB gene?
The GUSB gene provides instructions for producing an enzyme called beta-glucuronidase (β-glucuronidase). This enzyme is located in lysosomes, compartments within cells that digest and recycle different types of molecules. β-glucuronidase is involved in the breakdown of large molecules called glycosaminoglycans (GAGs). GAGs are composed of sugar molecules that are linked together to form a long string. To break down these large molecules, individual sugars are removed one at a time from one end of the molecule. β-glucuronidase is involved in the break down of three types of GAGs: dermatan sulfate, heparan sulfate, and chondroitin sulfate. This enzyme removes a sugar called glucuronic acid when it is at the end of the GAG chain.
How are changes in the GUSB gene related to health conditions?
Where is the GUSB gene located?
Cytogenetic Location: 7q21.11
Molecular Location on chromosome 7: base pairs 65,425,670 to 65,447,300
The GUSB gene is located on the long (q) arm of chromosome 7 at position 21.11.
More precisely, the GUSB gene is located from base pair 65,425,670 to base pair 65,447,300 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about GUSB?
You and your healthcare professional may find the following resources about GUSB helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the GUSB gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding GUSB?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.